MyD genes in negative growth control (original) (raw)

Review Article

Oncogene volume 17, pages 3319–3329 (1998)Cite this article

Abstract

Two interrelated cellular processes are invoked simultaneously upon induction of differentiation, the regulated progression of cells through successive stages of cell differentiation and growth inhibition which ultimately leads to growth arrest. In tissues with rapid cell turnover terminally differentiated cells undergo programmed cell death. Terminal differentiation, thus, represents one form of negative growth control. It was surmised that the molecular engine which drives the differentiation process forward requires induction of positive regulators of terminal cell differentiation, to be found among differentiation primary response genes, as well as suppression of negative regulators, which correspond to genes which control cellular growth. This line of thought has prompted the isolation of myeloid differentiation primary response (MyD) genes activated in the absence of de novo protein synthesis, upon IL-6 induced terminal differentiation of murine M1 myeloblastic leukemia cells, where the cells growth arrest and ultimately undergo programmed cell death. As delineated in this review many of the genes identified as MyD genes, including both known genes [IRF-1, (AP-1)Fos/Jun.EGR-1] and novel ones (MyD88, MyD116, MyD118), turned out to play a role in negative growth control, including growth suppression and apoptosis, in many cell types, of both hematopoietic and non hematopoietic origins.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 50 print issues and online access

$259.00 per year

only $5.18 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, 19140, Pennsylvania, USA
    Dan A Liebermann & Barbara Hoffman
  2. Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, 19140, Pennsylvania, USA
    Dan A Liebermann & Barbara Hoffman

Authors

  1. Dan A Liebermann
    You can also search for this author inPubMed Google Scholar
  2. Barbara Hoffman
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Liebermann, D., Hoffman, B. MyD genes in negative growth control.Oncogene 17, 3319–3329 (1998). https://doi.org/10.1038/sj.onc.1202574

Download citation

Keywords

This article is cited by