IFN-γ-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-γ response (original) (raw)

• Andrianifahanana M, Moniaux N, Schmied BM, Ringel J, Friess H, Hollingsworth MA et al. (2001). Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res 7: 4033–4040.
  CAS PubMed Google Scholar
• Boehm U, Klamp T, Groot M, Howard JC . (1997). Cellular responses to interferon-gamma. Annu Rev Immunol 15: 749–795.
  Article CAS Google Scholar
• Chatterjee-Kishore M, Wright KL, Ting JP, Stark GR . (2000). How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J 19: 4111–4122.
  Article CAS Google Scholar
• Choudhury A, Singh RK, Moniaux N, El-Metwally TH, Aubert JP, Batra SK . (2000). Retinoic acid-dependent transforming growth factor-beta 2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-alpha signaling pathway. J Biol Chem 275: 33929–33936.
  Article CAS Google Scholar
• Darnell Jr JE . (1997). STATs and gene regulation. Science 277: 1630–1635.
  Article CAS Google Scholar
• Darnell Jr JE, Kerr IM, Stark GR . (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421.
  Article CAS Google Scholar
• Decker T, Kovarik P . (2000). Serine phosphorylation of STATs. Oncogene 19: 2628–2637.
  Article CAS Google Scholar
• Goh KC, Haque SJ, Williams BR . (1999). p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J 18: 5601–5608.
  Article CAS Google Scholar
• Guo GG, Patel K, Kumar V, Shah M, Fried VA, Etlinger JD et al. (2002). Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes. J Interferon Cytokine Res 22: 555–563.
  Article CAS Google Scholar
• Kalvakolanu DV, Borden EC . (1996). An overview of the interferon system: signal transduction and mechanisms of action. Cancer Invest 14: 25–53.
  Article CAS Google Scholar
• Lagow EL, Carson DD . (2002). Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha. J Cell Biochem 86: 759–772.
  Article CAS Google Scholar
• Lee KA, Green MR . (1990). Small-scale preparation of extracts from radiolabeled cells efficient in pre-mRNA splicing. Methods Enzymol 181: 20–30.
  Article CAS Google Scholar
• Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W et al. (2005). Structural bases of unphosphorylated STAT1 association and receptor binding. Mol Cell 17: 761–771.
  Article CAS Google Scholar
• Marg A, Shan Y, Meyer T, Meissner T, Brandenburg M, Vinkemeier U . (2004). Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1. J Cell Biol 165: 823–833.
  Article CAS Google Scholar
• Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z et al. (1996). Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379: 645–648.
  Article CAS Google Scholar
• Meyer T, Marg A, Lemke P, Wiesner B, Vinkemeier U . (2003). DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev 17: 1992–2005.
  Article CAS Google Scholar
• Nelson JD, Denisenko O, Sova P, Bomsztyk K . (2006). Fast chromatin immunoprecipitation assay. Nucleic Acids Res 34: e2.
  Article Google Scholar
• Perrais M, Pigny P, Ducourouble MP, Petitprez D, Porchet N, Aubert JP et al. (2001). Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells. J Biol Chem 276: 30923–30933.
  Article CAS Google Scholar
• Shuai K, Stark GR, Kerr IM, Darnell Jr JE . (1993). A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 261: 1744–1746.
  Article CAS Google Scholar
• Singh AP, Chaturvedi P, Batra SK . (2007). Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. Cancer Res 67: 433–436.
  Article CAS Google Scholar
• Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK . (2004). Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 64: 622–630.
  Article CAS Google Scholar
• Suzuki K, Mori A, Ishii KJ, Saito J, Singer DS, Klinman DM et al. (1999). Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc Natl Acad Sci USA 96: 2285–2290.
  Article CAS Google Scholar
• Swartz MJ, Batra SK, Varshney GC, Hollingsworth MA, Yeo CJ, Cameron JL et al. (2002). MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol 117: 791–796.
  Article Google Scholar
• Yang J, Chatterjee-Kishore M, Staugaitis SM, Nguyen H, Schlessinger K, Levy DE et al. (2005). Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 65: 939–947.
  CAS PubMed Google Scholar
• Zhou Y, Wang S, Gobl A, Oberg K . (2001). Interferon alpha induction of Stat1 and Stat2 and their prognostic significance in carcinoid tumors. Oncology 60: 330–338.
  Article CAS Google Scholar