Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα (original) (raw)

• Aggarwal BB . (2004). Nuclear factor-kappaB: the enemy within. Cancer Cell 6: 203–208.
  Article CAS Google Scholar
• Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, Shigematsu H et al. (2005). Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res 65: 226–235.
  CAS PubMed Google Scholar
• Biswas DK, Cruz AP, Gansberger E, Pardee AB . (2000). Epidermal growth factor-induced nuclear factor kappaB activation: a major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci USA 97: 8542–8547.
  Article CAS Google Scholar
• Campbell KJ, Rocha S, Perkins ND . (2004). Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 13: 853–865.
  Article CAS Google Scholar
• Chaturvedi MM, Mukhopadhyay A, Aggarwal BB . (2000). Assay for redox-sensitive transcription factor. Methods Enzymol 319: 585–602.
  Article CAS Google Scholar
• Digicaylioglu M, Lipton SA . (2001). Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412: 641–647.
  Article CAS Google Scholar
• Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL . (1995). Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268: 726–731.
  Article CAS Google Scholar
• Finco TS, Baldwin Jr AS . (1993). kappaB site-dependent induction of gene expression by diverse inducers of nuclear factor kappaB requires Raf-1. J Biol Chem 268: 17676–17679.
  CAS PubMed Google Scholar
• Habib AA, Hognason T, Ren J, Stefansson K, Ratan RR . (1998). The epidermal growth factor receptor associates with and recruits phosphatidylinositol 3-kinase to the platelet-derived growth factor beta receptor. J Biol Chem 273: 6885–6891.
  Article CAS Google Scholar
• Han Y, Weinman S, Boldogh I, Walker RK, Brasier AR . (1999). Tumor necrosis factor-alpha-inducible I kappaB-alpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappaB activation. J Biol Chem 274: 787–794.
  Article CAS Google Scholar
• Haussler U, von Wichert G, Schmid RM, Keller F, Schneider G . (2005). Epidermal growth factor activates nuclear factor-kappaB in human proximal tubule cells. Am J Physiol Renal Physiol 289: F808–F815.
  Article Google Scholar
• Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV . (1996). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387–396.
  Article CAS Google Scholar
• Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C et al. (1996). Tyrosine phosphorylation of I kappa B-alpha activates NF-kappaB without proteolytic degradation of I kappa B-alpha. Cell 86: 787–798.
  Article CAS Google Scholar
• Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al. (2004). Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129–2139.
  Article CAS Google Scholar
• Malinin NL, Boldin MP, Kovalenko AV, Wallach D . (1997). MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 385: 540–544.
  Article CAS Google Scholar
• Mendelsohn J, Baselga J . (2000). The EGF receptor family as targets for cancer therapy. Oncogene 19: 6550–6565.
  Article CAS Google Scholar
• Mukhopadhyay A, Manna SK, Aggarwal BB . (2000). Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of I kappaB-alpha. Comparison with tumor necrosis factor-alpha. J Biol Chem 275: 8549–8555.
  Article CAS Google Scholar
• Obata H, Biro S, Arima N, Kaieda H, Kihara T, Eto H et al. (1996). NF-kappaB is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors. Biochem Biophys Res Commun 224: 27–32.
  Article CAS Google Scholar
• Pawson T . (1995). Protein modules and signalling networks. Nature 373: 573–580.
  Article CAS Google Scholar
• Singh S, Darnay BG, Aggarwal BB . (1996). Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation. J Biol Chem 271: 31049–31054.
  Article CAS Google Scholar
• Sun L, Carpenter G . (1998). Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium. Oncogene 16: 2095–2102.
  Article CAS Google Scholar
• Takada Y, Aggarwal BB . (2003). Betulinic acid suppresses carcinogen-induced NF-kappaB activation through inhibition of I kappaB alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol 171: 3278–3286.
  Article CAS Google Scholar
• Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB . (2004a). Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem 279: 39541–39554.
  Article CAS Google Scholar
• Takada Y, Khuri FR, Aggarwal BB . (2004b). Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis. J Biol Chem 279: 26287–26299.
  Article CAS Google Scholar
• Takada Y, Mukhopadhyay A, Kundu GC, Mahabeleshwar GH, Singh S, Aggarwal BB . (2003). Hydrogen peroxide activates NF-kappaB through tyrosine phosphorylation of I kappaB alpha and serine phosphorylation of p65: evidence for the involvement of I kappaB alpha kinase and Syk protein-tyrosine kinase. J Biol Chem 278: 24233–24241.
  Article CAS Google Scholar
• Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson BE, Janne PA . (2004). Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res 64: 7241–7244.
  Article CAS Google Scholar
• Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D et al. (2004). AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64: 4931–4941.
  Article CAS Google Scholar
• van der Geer P, Hunter T, Lindberg RA . (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10: 251–337.
  Article CAS Google Scholar
• Vinitsky A, Michaud C, Powers JC, Orlowski M . (1992). Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex. Biochemistry 31: 9421–9428.
  Article CAS Google Scholar