Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response (original) (raw)
Waxman DJ, Azaroff L . Phenobarbital induction of cytochrome P-450 gene expression Biochem J 1992 281 (Pt 3): 577–592 Article Google Scholar
Waxman DJ . P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR Arch Biochem Biophys 1999 369: 11–23 ArticleCAS Google Scholar
Honkakoski P, Negishi M . Regulation of cytochrome P450 (CYP) genes by nuclear receptors Biochem J 2000 347(Pt 2): 321–337 Article Google Scholar
Smith DA . Induction and drug development Eur J Pharm Sci 2000 11: 185–189 ArticleCAS Google Scholar
Thummel KE, Wilkinson GR . In vitro and in vivo drug interactions involving human CYP3A Annu Rev Pharmacol Toxicol 1998 38: 389–430 ArticleCAS Google Scholar
Honkakoski P, Moore R, Gynther J, Negishi M . Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes J Biol Chem 1996 271: 9746–9753 ArticleCAS Google Scholar
Honkakoski P, Negishi M . Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene J Biol Chem 1997 272: 14943–14949 ArticleCAS Google Scholar
Honkakoski P, Zelko I, Sueyoshi T, Negishi M . The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene Mol Cell Biol 1998 18: 5652–5658 ArticleCAS Google Scholar
Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M . The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene J Biol Chem 1999 274: 6043–6046 ArticleCAS Google Scholar
Tzameli I, Pissios P, Schuetz EG, Moore DD . The xenobiotic compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)] Benzene is an agonist ligand for the nuclear receptor CAR Mol Cell Biol 2000 20: 2951–2958 ArticleCAS Google Scholar
Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD . The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism Nature 2000 407: 920–923 ArticleCAS Google Scholar
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA et al . An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 1998 92: 73–82 ArticleCAS Google Scholar
Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES et al . SXR, a novel steroid and xenobiotic-sensing nuclear receptor Genes Dev 1998 12: 3195–3205 ArticleCAS Google Scholar
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA . The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions J Clin Invest 1998 102: 1016–1023 ArticleCAS Google Scholar
Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC et al . Humanized xenobiotic response in mice expressing nuclear receptor SXR Nature 2000 406: 435–439 ArticleCAS Google Scholar
Moore LB, Parks DJ, Jones SA, Bloe RK eds Consler TG, Stimmel JB et al . Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands J Biol Chem 2000 275: 15122–15127 ArticleCAS Google Scholar
Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B et al . Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR Genes Dev 2000 14: 3014–3023 ArticleCAS Google Scholar
Asoh M, Tateishi T, Kumai T, Kobayashi S . Induction of hepatic CYP2B in foetal and neonatal rats after maternal administration of phenobarbital Pharmacol Toxicol 1999 84: 18–23 ArticleCAS Google Scholar
Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA et al . CYP3A gene expression in human gut epithelium Pharmacogenetics 1994 4: 247–259 ArticleCAS Google Scholar
Smith G, Henderson CJ, Parker MG, White R, Bars RG, Wolf CR . 1,4-Bis[2-(3,5-dichloropyridyloxy)] benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression Biochem J 1993 289: 807–813 ArticleCAS Google Scholar
Noshiro M, Negishi M . Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver J Biol Chem 1986 261: 15923–15927 CASPubMed Google Scholar
Forman BM, Tzameli I, Choi HS, Chen J, Simha D, Seol W et al . Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta Nature 1998 395: 612–615 ArticleCAS Google Scholar
Honkakoski P, Moore R, Washburn KA, Negishi M . Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene Mol Pharmacol 1998 53: 597–601 ArticleCAS Google Scholar
Schuetz EG, Schmid W, Schutz G, Brimer C, Yasuda K, Kamataki T et al . The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver Drug Metab Dispos 2000 28: 268–278 CASPubMed Google Scholar
Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M . Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene Mol Cell Biol 1999 19: 6318–6322 ArticleCAS Google Scholar
Zelko I, Sueyoshi T, Kawamoto T, Moore R, Negishi M . The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver Mol Cell Biol 2001 21: 2838–2846 ArticleCAS Google Scholar
Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ . Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation Mol Pharmacol 2000 58: 1441–1450 ArticleCAS Google Scholar
Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA . Regulation of the human cyp2b6 gene by the nuclear pregnane x receptor Mol Pharmacol 2001 60: 427–431 CASPubMed Google Scholar
Paige LA, Christensen DJ, Gron H, Norris JD, Gottlin EB, Padilla KM et al . Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta Proc Natl Acad Sci U S A 1999 96: 3999–4004 ArticleCAS Google Scholar
Cholerton S, Daly AK, Idle JR . The role of individual human cytochromes P450 in drug metabolism and clinical response Trends Pharmacol Sci 1992 13: 434–439 ArticleCAS Google Scholar
Guengerich FP . Cytochrome P-450 3A4: regulation and role in drug metabolism Annu Rev Pharmacol Toxicol 1999 39: 1–17 ArticleCAS Google Scholar
Lee YK, Dell H, Dowhan DH, Hadzopoulou-Cladaras M, Moore DD . The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression Mol Cell Biol 2000 20: 187–195 ArticleCAS Google Scholar