Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis (original) (raw)

• Daza, P. et al. Mechanisms of nonhomologous DNA end-joining in frogs, mice and men. Biol. Chem. 377, 775– 786 (1996).
  CAS PubMed Google Scholar
• Jeggo, P.A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiation Res. 150, S80 –S91 (1998).
  Article CAS Google Scholar
• Takata, M. et al. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17, 5497–5508 (1998).
  Article CAS Google Scholar
• Sun, H., Treco, D., Schultes, N.P. & Szostak, J.W. Double-strand breaks at an initiation site for meiotic gene conversion. Nature 338, 87–90 ( 1989).
  Article CAS Google Scholar
• Baumann, P. & West, S.C. DNA end-joining catalyzed by human cell-free extracts. Proc. Natl Acad. Sci USA 95, 14066–14070 (1998).
  Article CAS Google Scholar
• Haber, J.E. The many interfaces of Mre11. Cell 95, 583 –586 (1998).
  Article CAS Google Scholar
• Nelms, B.E., Maser, R.S., MacKay, J.F., Lagally, M.G. & Petrini, J.J. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 280, 590–592 (1998).
  Article CAS Google Scholar
• Padmore, R., Cao, L. & Kleckner, N. Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae. Cell 66, 1239–1256 (1991).
  Article CAS Google Scholar
• Dolganov, G.M. et al. Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol. 16, 4832– 4841 (1996).
  Article CAS Google Scholar
• Singleton, B.K. et al. Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol. Cell. Biol. 17, 1264–1273 (1997).
  Article CAS Google Scholar
• Oakberg, E.F. Spermatogonial stem-cell renewal in the mouse. Anat. Rec. 169, 515–531 (1971).
  Article CAS Google Scholar
• Offenberg, H.H. et al. SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat. Nucleic Acids Res. 26, 2572–2579 (1998).
  Article CAS Google Scholar
• Lammers, J.H. et al. The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes. Mol. Cell. Biol. 14, 1137– 1146 (1994).
  Article CAS Google Scholar
• Critchlow, S.E. & Jackson, S.P. DNA-end-joining: from yeast to man. Trends Biochem. Sci. 23, 394–398 (1998).
  Article CAS Google Scholar
• Paull, T.T. & Gellert, M. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol. Cell 1, 969–979 ( 1998).
  Article CAS Google Scholar
• Moreau, S., Ferguson, J.R. & Symington, L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19, 556–566 (1999).
  Article CAS Google Scholar
• Furuse, M. et al. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 17, 6412–6425 (1998).
  Article CAS Google Scholar
• Usui, T. et al. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95, 705– 716 (1998).
  Article CAS Google Scholar
• Chua, P.R. & Roeder, G.S. Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Cell 93, 349–359 (1998).
  Article CAS Google Scholar
• Nairz, K. & Klein, F. Mre11S, a yeast mutation that blocks double-strand break processing and permits nonhomologous synapsis in meiosis. Genes Dev. 11, 2272–2290 (1997).
  Article CAS Google Scholar
• Tsukamoto, Y., Kato, J. & Ikeda, H. Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination. Nucleic Acids Res. 24, 2067–2072 (1996).
  Article CAS Google Scholar
• Martin, S.G., Laroche, T., Suka, N., Grunstein, M. & Gasser, S. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97, 621–633 (1999).
  Article CAS Google Scholar
• Chu, S. et al. The transcriptional program of sporulation in budding yeast. Science 282, 699–705 (1998).
  Article CAS Google Scholar
• Schwacha, A. & Kleckner, N. Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis. Cell 76, 51– 63 (1994).
  Article CAS Google Scholar
• Golemis, E.A. & Khazak, V. Alternative yeast two-hybrid systems. The interaction trap and interaction mating. Methods Mol. Biol. 63, 197–218 ( 1997).
  CAS PubMed Google Scholar
• Jung, V. et al. Two types of RAS mutants that dominantly interfere with activators of RAS. Mol. Cell. Biol. 14, 3707– 3718 (1998).
  Article Google Scholar
• Keeney, S., Giroux, C.N. & Kleckner, N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88, 375–384 (1997).
  Article CAS Google Scholar
• Bergerat, A. et al. An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature 386, 414 –417 (1997).
  Article CAS Google Scholar
• Tsubouchi, H. & Ogawa, H. A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis. Mol. Cell. Biol. 18, 260–268 (1998).
  Article CAS Google Scholar
• Sun, H.D., Treco, D. & Szostak, J.W. Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell 64, 1155–1161 (1991).
  Article CAS Google Scholar
• Moore, J.K. & Haber, J.E. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 2164–2173 (1996).
  Article CAS Google Scholar