Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse (original) (raw)

Nature Genetics volume 23, pages 268–270 (1999)Cite this article

The sebaceous gland has an important role in hair biology1. The asebia (ab) mutant mouse has rudimentary sebaceous glands and develops alopecia2,3; here we elucidate the genetic basis for this recessive phenotype. Histopathological studies of ab J (ABJ/Le ab J/ab J; ref. 3 ) and recently discovered ab 2J (DBA/1LacJ -ab 2J /ab 2J; J.P.S., unpublished data) allelic mice indicate that the hair shaft in these mice, which is unable to shed its sheath, grows in reverse toward the subcutis, leading to chronic foreign body inflammatory reactions followed by follicle loss and dermal scarring in adult mutant mice. Recently we reported high-resolution genetic mapping of the ab 2J mutation4. On the basis of the altered profile of skin surface lipids in mutant mice and the known genes within the 1.6-cM mapped interval, we considered the genes encoding stearoyl-CoA desaturase 1 (Scd1) and stearoyl-coA desaturase 2 (Scd2) as potential candidates for the ab mutation (refs 5, 6, 7, 8, 9).

Unlike rodents, which exhibit tissue-specific and inducible expression of Scd1 and Scd2, a functional SCD and its pseudogene exist in humans11. We are unaware of a direct parallel between the ab mutation and a human disorder, but the small sebaceous glands and the associated scarring alopecia of mutant mice are reminiscent of some of the clinical scarring alopecias12.

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References

  1. Williams, D.D. & Stenn, K.S. Dev. Biol. 165, 469–479 (1994).
    Article CAS Google Scholar
  2. Gates, A.H. & Karasek, M. Science 148, 1471–1473 (1965).
    Article CAS Google Scholar
  3. Josefowicz, W.J. & Hardy, M.H. Genet. Res. Camb. 31, 145–166 ( 1978).
    Article Google Scholar
  4. Eilertsen, K.J., Tran, T., Sundberg, J.P., Stenn, K.S. & Parimoo, S. J. Exp. Anim. Sci. (in press).
  5. Ntambi, J.M. et al. J. Biol. Chem. 263, 17291– 17300 (1988).
    CAS PubMed Google Scholar
  6. Kaestner, K.H., Ntambi, J.M., Kelly, T.J. Jr & Lane, M.D. J. Biol. Chem. 264, 14755–14761 (1989).
    CAS PubMed Google Scholar
  7. Wilkinson, D.I. & Karasek, M.A. J. Invest. Dermatol. 47, 449–455 ( 1966).
    Article CAS Google Scholar
  8. Ntambi, J.M. Prog. Lipid Res. 34, 139–150 (1995).
    Article CAS Google Scholar
  9. Tabor, D.E., Xia, Y.R., Mehrabian, M., Edwards, P.A. & Lusis, A.J. Mamm. Genome 9, 341– 342 (1998).
    Article CAS Google Scholar
  10. Stenn, K.S., Paus, R., Dutton, T. & Sarba, B. Skin Pharmacol. 6, 125–134 ( 1993).
    Article CAS Google Scholar
  11. Zhang, L., Ge, L., Parimoo, S., Stenn, K. & Prouty, S.M. Biochem. J. 340, 255– 264 (1999).
    Article CAS Google Scholar
  12. Sperling, L.C. & Sau, P. Arch. Dermatol. 128, 68–74 (1992).
    Article CAS Google Scholar
  13. Shinomura, T., Asaoka, Y., Oka, M., Yoshida, K. & Nishizuka, Y. Proc. Natl Acad. Sci. USA 88, 5149–5153 (1991).
    Article CAS Google Scholar
  14. Hanley, K., et al. J. Invest. Dermatol. 110, 368– 375 (1998).
    Article CAS Google Scholar
  15. Downing, D.T., Stewart, M.E., Wertz, P.W. & Strauss, J.S. J. Am. Acad. Dermatol. 14, 221–225 (1986).
    Article CAS Google Scholar

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Acknowledgements

We thank M. Eisinger for critical review of the manuscript.

Author information

Author notes

  1. Kenneth J. Eilertsen
    Present address: Infigen, Inc., DeForest, Wisconsin, USA
  2. Ying Zheng and Kenneth J. Eilertsen: These authors contributed equally to this work.

Authors and Affiliations

  1. Johnson & Johnson Skin Biology TRC, Skillman, New Jersey, USA
    Ying Zheng, Kenneth J. Eilertsen, Lan Ge, Lin Zhang, Stephen M. Prouty, Kurt S. Stenn & Satish Parimoo
  2. The Jackson Laboratory, Bar Harbor, Maine, USA
    John P. Sundberg

Authors

  1. Ying Zheng
  2. Kenneth J. Eilertsen
  3. Lan Ge
  4. Lin Zhang
  5. John P. Sundberg
  6. Stephen M. Prouty
  7. Kurt S. Stenn
  8. Satish Parimoo

Corresponding author

Correspondence toSatish Parimoo.

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Zheng, Y., Eilertsen, K., Ge, L. et al. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse.Nat Genet 23, 268–270 (1999). https://doi.org/10.1038/15446

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