Evidence for the Presence of Noradrenaline in Submicroscopic Structures of Adrenergic Axons (original) (raw)

Nature volume 177, pages 44–45 (1956)Cite this article

Abstract

THE presence of sympathomimetic activity in adrenergic nerve tissue has been demonstrated by several authors1. The active substance later was shown to possess the characteristic biological and chemical properties of noradrenaline2. A comparison of the relative contents of noradrenaline in splenic nerves (10–20 µgm. per gm.) and the spleen (2–4 µgm. per gm.) suggests that the transmitter is accumulated in the terminal parts of the nerves. Certain substances, such as acids, detergents and digitonin, which release catechol amines from adrenal medullary cell granules3, also release the adrenergic transmitter from a perfused organ4. Moreover, since the adrenergic nerves may be regarded as homologues of the adrenal medullary cells, it may be expected that their specific action substance is similarly stored.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Gaddum, J. H., and Khayyal, M. A., quoted from Gaddum, “_Gefässerweiternde Stoffe der Gewebe_” (Georg Thieme, Leipzig, 1936). Lissák, K., Amer. J. Physiol., 125, 778 (1939).
    Google Scholar
  2. Euler, U. S. v., Acta Physiol. Scand., 16, 63 (1948); 19, 207 (1949).
    Article Google Scholar
  3. Hillarp, N.-Å., Lagerstedt, S., and Nilson, B., Acta Physiol. Scand., 29, 251 (1953). Hillarp, N.-Å., and Nilson, B., Acta Physiol. Scand., 31, Supp. 113, 79 (1954). Blaschko, H., and Welch, A. D., Arch. exp. Path. u. Pharmakol., 219, 17 (1953).
    Article CAS Google Scholar
  4. Eliasson, R., Euler, U. S. v., and Stjärne, L., Acta Physiol. Scand., Supp. 118 (1955). Euler, U. S. v., and Stjärne, L., Acta Physiol. Scand., 33, Supp. 118 (1955).
  5. Euler, U. S. v., Acta Physiol. Scand., 19, 85 (1949).
    Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Stockholm
    U. S. von EULER
  2. Department of Histology, University, Lund,
    N.-Å. HILLARP

Authors

  1. U. S. von EULER
    You can also search for this author inPubMed Google Scholar
  2. N.-Å. HILLARP
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

EULER, U., HILLARP, NÅ. Evidence for the Presence of Noradrenaline in Submicroscopic Structures of Adrenergic Axons.Nature 177, 44–45 (1956). https://doi.org/10.1038/177044b0

Download citation