Pharmacological Inhibition of Acetylcholine Synthesis (original) (raw)
- Letter
- Published: 24 November 1956
Nature volume 178, page 1181 (1956)Cite this article
- 863 Accesses
- 162 Citations
- Metrics details
Abstract
SCHUELER1 has designated as the “hemicholiniums” a series of quaternary bases2 which exhibit an unusual kind of toxicity. Chemically they are characterized by the incorporation of a choline (or choline-like) moiety into a six-membered ring through hemiacetal formation. Their most striking pharmacological action is respiratory paralysis: this is central in origin and late in onset, and when the dose is not too large can be prevented by the administration of either eserine or choline. Schueler noted that hemi-cholinium intoxication presents several features reminiscent of poisoning by botulinus or tetanus toxin, and suggested that it might be due to interference with some cholinergic mechanism. We thought that a substance having such effects might be a specific poison of acetylcholine synthesis, and through Dr. Schueler's kindness we have been able to verify this notion with compound No. 3 of his series, here called _HC_3.
Similar content being viewed by others
Article PDF
References
- Schueler, F. W., J. Pharmacol., 115, 127 (1955).
CAS Google Scholar - Long, J. P., and Schueler, F. W., J. Amer. Pharm. Assoc. (Sc. Ed.), 43, 79 (1954).
Article CAS Google Scholar - Perry, W. L. M., J. Physiol., 119, 439 (1953).
Article CAS Google Scholar - Shelley, H., J. Physiol., 131, 329 (1956).
Article CAS Google Scholar - Mann, P. J. G., Tennenbaum, M., and Quastel, J. H., Biochem. J., 33, 822 (1939).
Article CAS Google Scholar - Lipmann, F., J. Biol. Chem., 160, 173 (1945).
CAS Google Scholar
Author information
Authors and Affiliations
- Department of Physiology, McGill University, Montreal
F. C. MACINTOSH, R. I. BIRKS & P. B. SASTRY
Authors
- F. C. MACINTOSH
You can also search for this author inPubMed Google Scholar - R. I. BIRKS
You can also search for this author inPubMed Google Scholar - P. B. SASTRY
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
MACINTOSH, F., BIRKS, R. & SASTRY, P. Pharmacological Inhibition of Acetylcholine Synthesis.Nature 178, 1181 (1956). https://doi.org/10.1038/1781181a0
- Issue Date: 24 November 1956
- DOI: https://doi.org/10.1038/1781181a0
This article is cited by
Die Wirkungβ-adrenerger Substanzen auf die exokrine Funktion des Pankreas
- E. Heidbreder
- P. Sieber
- A. Heidland
Research in Experimental Medicine (1977)
Evidence against cholinergic mediation of the effect of angiotensin II on the guinea pig ileum
- Therezinha B. Paiva
- Gun B. Mendes
- Antonio C. M. Paiva
Pfl�gers Archiv European Journal of Physiology (1976)