Disappearance of Oxytetracycline Accumulation in the Cells of Multiple Drug-resistant Escherichia coli (original) (raw)

Nature volume 200, pages 384–385 (1963)Cite this article

Abstract

IN a previous communication1 we described the accumulation of a large amount of oxytetracycline related to the bactericidal action in the cells of E. coli. This accumulation seemed to be dependent on an energy-yielding system, since the presence of glucose was needed for the accumulation of oxytetracycline, and inhibitors such as 2,4-dmitrophenol and sodium azide inhibited the accumulation at low concentrations at which oxidation of glucose by the resting cells was not inhibited. However, recently, multiple drug-resistant bacteria have been found by many Japanese workers and many biochemical and genetic studies on these bacteria have been carried out2–6.

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Authors and Affiliations

  1. Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo,
    KAZUO IZAKI & KEI ARIMA

Authors

  1. KAZUO IZAKI
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  2. KEI ARIMA
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IZAKI, K., ARIMA, K. Disappearance of Oxytetracycline Accumulation in the Cells of Multiple Drug-resistant Escherichia coli.Nature 200, 384–385 (1963). https://doi.org/10.1038/200384a0

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