Disappearance of Oxytetracycline Accumulation in the Cells of Multiple Drug-resistant Escherichia coli (original) (raw)
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- Published: 26 October 1963
Nature volume 200, pages 384–385 (1963)Cite this article
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Abstract
IN a previous communication1 we described the accumulation of a large amount of oxytetracycline related to the bactericidal action in the cells of E. coli. This accumulation seemed to be dependent on an energy-yielding system, since the presence of glucose was needed for the accumulation of oxytetracycline, and inhibitors such as 2,4-dmitrophenol and sodium azide inhibited the accumulation at low concentrations at which oxidation of glucose by the resting cells was not inhibited. However, recently, multiple drug-resistant bacteria have been found by many Japanese workers and many biochemical and genetic studies on these bacteria have been carried out2–6.
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Authors and Affiliations
- Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo,
KAZUO IZAKI & KEI ARIMA
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- KAZUO IZAKI
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IZAKI, K., ARIMA, K. Disappearance of Oxytetracycline Accumulation in the Cells of Multiple Drug-resistant Escherichia coli.Nature 200, 384–385 (1963). https://doi.org/10.1038/200384a0
- Issue Date: 26 October 1963
- DOI: https://doi.org/10.1038/200384a0