3-Methoxy-4 5-methylenedioxy Amphetamine, a New Psychotomimetic Agent (original) (raw)

Nature volume 201, pages 1120–1121 (1964) Cite this article

Abstract

THE establishment of trimethoxyamphetamine (I_b_, TMA) as being of greater psychotropic potency than either α-ethyl mescaline (I_c_) (ref. 1) or mescaline itself (I_a_) (ref. 2) has led to the examination of analogues which retain the three carbon chain but vary in other areas of the molecule. The presence of elemicin (3,4,5-trimethoxy allylbenzene) in the aromatic ether fraction of oil of nutmeg3, and the proposal of a possible in vivo mechanism for its conversion to TMA (ref. 4) have afforded an explanation of the psychotropic action5 of nutmeg. The substance myristicin (II) is the major component of this fraction, and if it were to undergo a transformation parallel to that proposed for elemicin, a second amphetamine, 3-methoxy-4 5-methylenedioxy amphetamine (MMDA, IV_a_), would result.

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References

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Authors and Affiliations

  1. Dow Chemical Co., Western Division, Walnut Creek, California
    ALEXANDER T. SHULGIN

Authors

  1. ALEXANDER T. SHULGIN

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SHULGIN, A. 3-Methoxy-4 5-methylenedioxy Amphetamine, a New Psychotomimetic Agent.Nature 201, 1120–1121 (1964). https://doi.org/10.1038/2011120a0

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  1. H. Tomasz Grzybowski 22 March 2018, 17:58
    Caution: sometimes DOB or DOM are sold as LSD. They are hallucinogenic psychedelics which suppress subconsciousness and may cause negative changes of personality.
    It is very good that Alexander Shulgin introduced MDMA to psychotherapists. My email is htg@interia.pl