An Unidentified Virus which causes the Rapid Production of Tumours in Mice (original) (raw)

Nature volume 204, pages 1104–1105 (1964)Cite this article

Abstract

IN the course of routine passage of Moloney's leukæmogenic virus (MLV) plasma was collected from a leukæmic rat (Chester Beatty Institute outbred albino strain) which had been inoculated with MLV-containing mouse plasma when new-born. After storage at −70°C for three months the rat plasma was diluted 1 in 30 with Hanks's saline and passed through a ‘Selas 02’ filter, tested and found impervious to Esch. coli. The filtrate was injected into 15 new-born BALB/c mice, as a test of potency. Only 6 survived to weaning. On the 32nd day 5 had tumours at or near the injection site, and all had grossly enlarged spleens. Usually mice inoculated with MLV remain symptomless until they show the characteristic signs of leukæmia after 8 weeks.

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References

  1. Fink, A. W., and Rauscher, F. J., J. Nat. Cancer Inst., 32, 1075 (1964).
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Authors and Affiliations

  1. Cancer Research Department, London Hospital Research Laboratories, London, E.1
    J. J. HARVEY

Authors

  1. J. J. HARVEY
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HARVEY, J. An Unidentified Virus which causes the Rapid Production of Tumours in Mice.Nature 204, 1104–1105 (1964). https://doi.org/10.1038/2041104b0

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