An Unidentified Virus which causes the Rapid Production of Tumours in Mice (original) (raw)
- Letter
- Published: 01 December 1964
Nature volume 204, pages 1104–1105 (1964)Cite this article
- 1931 Accesses
- 364 Citations
- 4 Altmetric
- Metrics details
Abstract
IN the course of routine passage of Moloney's leukæmogenic virus (MLV) plasma was collected from a leukæmic rat (Chester Beatty Institute outbred albino strain) which had been inoculated with MLV-containing mouse plasma when new-born. After storage at −70°C for three months the rat plasma was diluted 1 in 30 with Hanks's saline and passed through a ‘Selas 02’ filter, tested and found impervious to Esch. coli. The filtrate was injected into 15 new-born BALB/c mice, as a test of potency. Only 6 survived to weaning. On the 32nd day 5 had tumours at or near the injection site, and all had grossly enlarged spleens. Usually mice inoculated with MLV remain symptomless until they show the characteristic signs of leukæmia after 8 weeks.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Fink, A. W., and Rauscher, F. J., J. Nat. Cancer Inst., 32, 1075 (1964).
CAS PubMed Google Scholar - Gledhill, A. W., Brit. J. Cancer, 15, 531 (1961).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Cancer Research Department, London Hospital Research Laboratories, London, E.1
J. J. HARVEY
Authors
- J. J. HARVEY
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
HARVEY, J. An Unidentified Virus which causes the Rapid Production of Tumours in Mice.Nature 204, 1104–1105 (1964). https://doi.org/10.1038/2041104b0
- Published: 01 December 1964
- Issue Date: 12 December 1964
- DOI: https://doi.org/10.1038/2041104b0