Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine (original) (raw)

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• Published: 05 June 1965

Nature volume 206, page 1052 (1965)Cite this article

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Abstract

TRYPTAMINE is a normal constituent of human urine1–5; about 30–120 µg of the amine are excreted per 24 h. In blood, tryptamine has hitherto been demonstrated only qualitatively and under pathological conditions in a carcinoid patient6. There is no information about an occurrence of N,_N_-dimethyltryptamine in human beings. N,_N_-dimethyl-5-hydroxytryptamine (= Bufotenin) was demonstrated qualitatively as a constituent of normal human urine4,7; in children an excretion of 0–0.03 µg amine/100 mg creatinine has been found with, at most, semi-quantitative methods4. Apparently, N,_N_-dimethyl-5-hydroxytryptamine was still not demonstrated in blood. 5-Methoxytryptamine has been found in the urine of patients with rheumatic fever8, and that in an order of magnitude of 30–210 µg/24 h.

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1. 5 Köln-Marienburg, Ulmenallee, 3
   FR. FRANZEN & H. Gross

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1. FR. FRANZEN
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2. H. Gross
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FRANZEN, F., Gross, H. Tryptamine, N,_N_-Dimethyltryptamine, N,_N_-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine.Nature 206, 1052 (1965). https://doi.org/10.1038/2061052a0

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• Issue Date: 05 June 1965
• DOI: https://doi.org/10.1038/2061052a0

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