Muscle Contraction produced by Sulphydryl Inhibitors (original) (raw)

Nature volume 210, pages 1062–1063 (1966)Cite this article

Abstract

IT was recently reported1 that the sulphydryl (—SH) agent, parachloromercuribenzoate (PCMB), causes superprecipitation of actomyosin gel. Masking of an —SH group appears to prevent interaction between ATP and some inhibitory site on the protein, thus enabling ATP to induce superprecipitation through reaction with another site. If this phenomenon is related to changes occurring in the actomyosin system during muscle activity, then —SH agents should be expected to produce contraction. Accordingly, several such agents were tested on skeletal muscle, and they were found to cause various types of contractile phenomena.

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References

  1. Levy, H. M., and Ryan, E., Nature, 205, 703 (1965).
    Article ADS CAS PubMed Google Scholar
  2. Benesch, R., and Benesch, R. E., in Methods of Biochemical Analysis, (edit. by Glick, D.), 10, 43 (1962).
    MATH Google Scholar
  3. Abood, L. G., Koketsu, K., and Miyamoto, S., Amer. J. Physiol., 202, 469 (1962).
    CAS PubMed Google Scholar
  4. Luxoro, M., Rojas, E., and Wittig, E., J. Gen. Physiol., 46, 1109 (1963).
    Article CAS PubMed PubMed Central Google Scholar
  5. Kuperman, A. S., Volpert, W. A., and Okamoto, M., Nature, 204, 1000 (1964).
    Article ADS CAS PubMed Google Scholar

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Authors and Affiliations

  1. Department of Pharmacology, Cornell University Medical College, New York
    MICHIKO OKAMOTO & ALBERT S. KUPERMAN

Authors

  1. MICHIKO OKAMOTO
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  2. ALBERT S. KUPERMAN
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OKAMOTO, M., KUPERMAN, A. Muscle Contraction produced by Sulphydryl Inhibitors.Nature 210, 1062–1063 (1966). https://doi.org/10.1038/2101062a0

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