Efficacy of β-Adrenergic Blocking Agents in inducing Histamine Sensitivity in Mice (original) (raw)

Nature volume 217, pages 1173–1174 (1968)Cite this article

Abstract

THE usually high resistance of mice to the lethal effects of histamine can be greatly reduced in certain strains by some substances. The most potent of these histamine sensitizing substances is probably the so-called histamine sensitizing factor (HSF) of _Bordetella pertussis_1. Recently, substances with β-adrenergic blocking activity, such as dichloroiosoproterenol (DCI), pronethalol (‘Alderlin’R) and 4-(2-isopropyl-amino-1-hydroxyethyl) methane sulphonanilide HCl (_MJ_-1999), have also been shown to increase the sensitivity of mice to histamine2,3. Some of these agents, such as DCI, have been found highly effective in reducing histamine tolerance2. Preliminary work with DCI and the CFW strain of mice, reared in our laboratory, confirmed that treating mice with DCI does induce histamine sensitivity, but we did not find that DCI was effective in the small doses (0.005 mg/kg) reported by Fishel _et al._2. With the advent of other β-adrenergic blocking agents, we felt it would be of value to test the histamine sensitizing effects of these agents and to determine if some were more efficient in this respect than others. In order to duplicate more closely the experimental conditions used by Fishel _et al._2, we used female CFW mice obtained from Carworth Farms, New City, New York.

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References

  1. Munoz, J., and Bergman, R. K., J. Immunol., 97, 120 (1966).
    CAS PubMed Google Scholar
  2. Fishel, C. W., Szentivanyi, A., and Talmage, D. W., J. Immunol., 89, 8 (1962).
    CAS PubMed Google Scholar
  3. Townley, R. G., Trapani, I. L., and Szentivanyi, A., J. Allergy, 39, 177 (1967).
    Article CAS Google Scholar
  4. Bergman, R. K., and Munoz, J., Proc. Soc. Exp. Biol. and Med., 122, 428 (1966).
    Article CAS Google Scholar
  5. Fishel, C. W., Szentivanyi, A., and Talmage, D. W., in Bacterial Endotoxins (edit. by Landy, M., and Braun, W.), 474 (Quinn and Boden Co., Rahway, New Jersey, 1964).
    Google Scholar
  6. Szentivanyi, A., Fishel, C. W., and Talmage, D. W., J. Infect. Dis., 113, 86 (1963).
    Article CAS Google Scholar
  7. Fishel, C. W., and Szentivanyi, A., J. Allergy, 34, 439 (1963).
    Article CAS Google Scholar
  8. Reed, L. J., and Muench, H., Amer. J. Hygiene, 27, 493 (1938).
    Google Scholar
  9. Nickerson, M., as quoted by Wolfson, S., and Gorlin, R., in Ann. NY Acad. Sci., 139, 1003 (1967).
    Article Google Scholar

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Authors and Affiliations

  1. Rocky Mountain Laboratory, US National Institute of Allergy and Infectious Diseases, Hamilton, Montana
    R. K. BERGMAN & J. MUNOZ

Authors

  1. R. K. BERGMAN
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  2. J. MUNOZ
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BERGMAN, R., MUNOZ, J. Efficacy of _β_-Adrenergic Blocking Agents in inducing Histamine Sensitivity in Mice.Nature 217, 1173–1174 (1968). https://doi.org/10.1038/2171173a0

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