Enumeration of the Oxygen Sensitive Bacteria usually Present in the Intestine of Healthy Mice (original) (raw)

Nature volume 220, pages 1137–1139 (1968)Cite this article

Abstract

THE gastrointestinal microflora of specific pathogen free mice usually includes several species of anaerobic bacteria. In a healthy state these organisms greatly outnumber the coliform bacilli and enterococci that are commonly but erroneously assumed to be the most characteristic inhabitants of the intestinal tract1–3. Earlier publications from this laboratory have presented the hypothesis that several species of anaerobic bacteria have evolved with the mouse, live symbiotically with it and play essential parts in its anatomical development as well as in physiological functions. Such organisms are intimately associated with gastrointestinal anatomy and can be regarded as constituting its autochthonous microflora. This hypothesis, if valid, applies equally well to other omnivorous animals, including man1–3.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Dubos, R., Schaedler, R. W., Costello, R., and Hoet, P., J. Exp. Med., 122, 67 (1965).
    Article CAS Google Scholar
  2. Dubos, R., Carworth Europe Collected Papers, 2, 11 (1968).
    Google Scholar
  3. Dubos, R., Gastroenterology, 51, 868 (1966).
    PubMed CAS Google Scholar
  4. Savage, D. C., and Dubos, R., J. Exp. Med., 128, 97 (1968).
    Article CAS Google Scholar
  5. Savage, D. C., Dubos, R., and Schaedler, R. W., J. Exp. Med., 127, 67 (1968).
    Article CAS Google Scholar
  6. Hungate, R. E., Bact. Rev., 14, 1 (1950).
    PubMed CAS Google Scholar
  7. Drasar, B. S., J. Pathol. Bact., 94, 417 (1967).
    Article CAS Google Scholar
  8. Aranki, A., Syed, S. A., and Freter, R., Bact. Proc., 68, 94 (1968).
    Google Scholar
  9. Schaedler, R. W., Dubos, R., and Costello, R., J. Exp. Med., 122, 59 (1965).
    Article CAS Google Scholar

Download references

Author information

Author notes

  1. ADRIAN LEE
    Present address: Department of Medical Microbiology, University of New South Wales, Sydney, Australia

Authors and Affiliations

  1. Rockefeller University, New York
    ADRIAN LEE, JAMES GORDON & RENÉ DUBOS

Authors

  1. ADRIAN LEE
    You can also search for this author inPubMed Google Scholar
  2. JAMES GORDON
    You can also search for this author inPubMed Google Scholar
  3. RENÉ DUBOS
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

LEE, A., GORDON, J. & DUBOS, R. Enumeration of the Oxygen Sensitive Bacteria usually Present in the Intestine of Healthy Mice.Nature 220, 1137–1139 (1968). https://doi.org/10.1038/2201137a0

Download citation