Amplifying and Suppressive Effect of Thymus Cells (original) (raw)
- Letter
- Published: 31 December 1971
Nature volume 234, pages 549–551 (1971)Cite this article
- 30 Accesses
- 80 Citations
- Metrics details
Abstract
THE humoral immune response against a variety of antigens in mice requires the interaction of an antibody forming precursor cell derived from bone marrow (AFPC) and a thymus-derived helper cell1–3. In the chicken, plasma cell formation and immunoglobulin synthesis are ontogenetically controlled by the bursa of Fabricius4, suggesting that in this species the bursa provides the AFPC, but it is not clear what role the thymus plays in the humoral antibody production. Neonatal thymectomy of chickens does affect antibody formation, at least towards some antigens5,6; and by analogy with mice7,8 thymus dependency varies strongly with the antigen dose and also with respect to the class of antibody affected (W. D., and Malchow, D., unpublished work). Attempts to demonstrate a synergistic effect between thymus and bursa cells in the chicken, however, have not been successful7,10. I wish to describe experiments indicating that thymus cells can cooperate with a bursa-dependent component in the production of agglutinating antibodies and also that in a different experimental situation thymus cells show a suppressive effect on antibody formation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Claman, H. N., Chaperon, E. A., and Triplett, R. F., Proc. Soc. Exp. Biol. Med., 122, 1167 (1966).
Article CAS PubMed Google Scholar - Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1968).
Article CAS PubMed PubMed Central Google Scholar - Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 821 (1968).
Article CAS PubMed PubMed Central Google Scholar - Cooper, M. D., Peterson, R. D. A., South, M. A., and Good, R. A., J. Exp. Med., 123, 75 (1966).
Article CAS PubMed PubMed Central Google Scholar - Graetzer, M. A., Wolfe, H. R., Aspinall, R. L., and Meyer, R. K., J. Immunol., 90, 878 (1963).
CAS PubMed Google Scholar - Cooper, M. D., Peterson, R. D. A., and Good, R. A., Nature, 205, 143 (1965).
Article ADS CAS PubMed Google Scholar - Sinclair, N. R. St C., and Elliott, E. V., Immunology, 15, 325 (1968).
CAS PubMed PubMed Central Google Scholar - Taylor, R. B., and Wortis, H. H., Nature, 220, 927 (1968).
Article ADS CAS PubMed Google Scholar - Gilmour, D. G., Theis, G. A., and Thorbecke, G. J., J. Exp. Med., 132, 134 (1970).
Article CAS PubMed PubMed Central Google Scholar - Claflin, A. J., Smithies, O., and Meyer, J. K., J. Immunol., 97, 693 (1966).
CAS PubMed Google Scholar - Wegmann, T. G., and Smithies, O., Transfusion, 8, 47 (1968).
Article CAS PubMed Google Scholar - Martin, W. J., and Miller, J. F. A. P., J. Exp. Med., 128, 855 (1968).
Article CAS PubMed PubMed Central Google Scholar - Baker, P. J., Stashak, P. W., Amsbaugh, D. F., Prescott, B., and Barth, R. F., J. Immunol., 105, 1581 (1970).
CAS PubMed Google Scholar - Droege, W., and Strominger, J. L., Fed. Proc., 29, 698 (1970).
Google Scholar
Author information
Authors and Affiliations
- Biological Laboratories, Harvard University, Cambridge, Massachusetts, 02138
WULF DROEGE
Authors
- WULF DROEGE
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
DROEGE, W. Amplifying and Suppressive Effect of Thymus Cells.Nature 234, 549–551 (1971). https://doi.org/10.1038/234549a0
- Received: 25 May 1971
- Issue Date: 31 December 1971
- DOI: https://doi.org/10.1038/234549a0