Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells (original) (raw)

Nature volume 248, pages 590–592 (1974)Cite this article

Abstract

HUMAN adenoviruses undergo a complete cycle of replication in human cells, but cause an abortive infection in simian cells. In the simian cells infected with the human adenovirus, early adenovirus-specific T antigen is induced1,2, viral DNA is replicated to the same level as in productive cycles of replication3,4, and no change in the synthesis of viral mRNA can be detected5,6. However, only limited amounts of viral capsid proteins are made in relatively few cells1,2,6–8. If the simian cells are coinfected with simian virus 40 (SV40), the nonproductive cycle of replication of human adenoviruses is changed to a productive cycle9,10. This helper effect of infection by SV40 is thought to be under the control of SV40 gene function, but there has been no direct evidence for this. Using temperature-sensitive (ts) mutants of SV40, I have now found such evidence.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

Viral gene drive in herpesviruses

Article Open access 28 September 2020

References

  1. Feldman, L. A., Butel, J. S., and Rapp, F., J. Bact., 91, 813 (1966).
    CAS PubMed Google Scholar
  2. Malmgren, R. A., Rabson, A. S., Carney, P. G., and Paul, F. J., J. Bact., 91, 262 (1966).
    CAS PubMed Google Scholar
  3. Rapp, F., Feldman, L. A., and Mandel, M., J. Bact., 92, 931 (1966).
    CAS PubMed Google Scholar
  4. Reich, P. R., Baum, S. G., Rose, J. A., Rowe, W. P., and Weissman, S. M., Proc. natn. Acad. Sci. U.S.A., 55, 336 (1966).
    Article ADS CAS Google Scholar
  5. Baum, S. G., Wiese, W. H., and Reich, P. R., Virology, 34, 373 (1968).
    Article CAS Google Scholar
  6. Lucas, J. L., and Ginsberg, H. S., J. Virol., 10, 1109 (1972).
    CAS PubMed PubMed Central Google Scholar
  7. Friedman, M. P., Lyons, M. J., and Ginsberg, H. S., J. Virol., 5, 586 (1970).
    CAS PubMed PubMed Central Google Scholar
  8. Henry, C. J., Slifkin, M., and Merkov, L., Nature new Biol. 233, 39 (1971).
    Article ADS CAS Google Scholar
  9. Rabson, A. S., O'Conor, G. T., Berezesky, I. K., and Paul, F. J., Proc. Soc. exp. biol. Med., 116, 187 (1964).
    Article CAS Google Scholar
  10. Beardmore, W. B., Havlick, M. J., Serafini, A., and McLean, I. W., jun., J. Immun., 95, 422 (1965).
    CAS PubMed Google Scholar
  11. Kimura, G., and Dulbecco, R., Virology, 49, 394 (1972).
    Article CAS Google Scholar
  12. Kimura, G., and Dulbecco, R., Virology, 52, 529 (1973).
    Article CAS Google Scholar
  13. Jerkofsky, M., and Rapp, F., J. Virol., 2, 670 (1968).
    CAS PubMed PubMed Central Google Scholar
  14. Jerkofsky, M., and Rapp, F., Virology, 51, 466 (1973).
    Article CAS Google Scholar
  15. O'Conor, G. T., Rabson, A. S., Berezesky, I. K., and Paul, F. J., J. natn. Cancer Inst., 31, 903 (1963).
    CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Bacteriology, Tottori University School of Medicine, Yonago, 683
    GENKI KIMURA

Authors

  1. GENKI KIMURA
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

KIMURA, G. Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells.Nature 248, 590–592 (1974). https://doi.org/10.1038/248590a0

Download citation