Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells (original) (raw)
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- Published: 12 April 1974
Nature volume 248, pages 590–592 (1974)Cite this article
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Abstract
HUMAN adenoviruses undergo a complete cycle of replication in human cells, but cause an abortive infection in simian cells. In the simian cells infected with the human adenovirus, early adenovirus-specific T antigen is induced1,2, viral DNA is replicated to the same level as in productive cycles of replication3,4, and no change in the synthesis of viral mRNA can be detected5,6. However, only limited amounts of viral capsid proteins are made in relatively few cells1,2,6–8. If the simian cells are coinfected with simian virus 40 (SV40), the nonproductive cycle of replication of human adenoviruses is changed to a productive cycle9,10. This helper effect of infection by SV40 is thought to be under the control of SV40 gene function, but there has been no direct evidence for this. Using temperature-sensitive (ts) mutants of SV40, I have now found such evidence.
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Authors and Affiliations
- Department of Bacteriology, Tottori University School of Medicine, Yonago, 683
GENKI KIMURA
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- GENKI KIMURA
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KIMURA, G. Genetic evidence for SV40 gene function in enhancement of replication of human adenovirus in simian cells.Nature 248, 590–592 (1974). https://doi.org/10.1038/248590a0
- Received: 23 October 1973
- Revised: 18 January 1974
- Issue Date: 12 April 1974
- DOI: https://doi.org/10.1038/248590a0