Effect of tumour necrosis factor on cultured human melanoma cells (original) (raw)

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• Published: 25 December 1975

Nature volume 258, pages 731–732 (1975)Cite this article

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Abstract

CARSWELL _et al._1 described a tumour necrosis factor (TNF) in the sera of mice sensitised with BCG and injected with endotoxin. After intravenous injection of this serum into mice bearing a 7-d-old transplant of a tumour originally induced by methylcholanthrene, necrosis of the tumour began within 12–24 h. A similar response was found in mice bearing various other tumours. We have now found that both whole TNF serum and TNF partially purified from mouse serum2 inhibit the growth of a human melanoma cell line.

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References

1. Carswell, E. A., et al., Proc. natn. Acad. Sci. U.S.A., 72, 3666–3670 (1975).
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Authors and Affiliations

1. Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021
   LAWRENCE HELSON, SAUL GREEN, ELIZABETH CARSWELL & LLOYD J. OLD

Authors

1. LAWRENCE HELSON
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2. SAUL GREEN
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3. ELIZABETH CARSWELL
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4. LLOYD J. OLD
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HELSON, L., GREEN, S., CARSWELL, E. et al. Effect of tumour necrosis factor on cultured human melanoma cells.Nature 258, 731–732 (1975). https://doi.org/10.1038/258731a0

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• Received: 24 January 1975
• Accepted: 30 October 1975
• Issue Date: 25 December 1975
• DOI: https://doi.org/10.1038/258731a0

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