Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family (original) (raw)

Nature volume 267, pages 23–28 (1977)Cite this article

Abstract

Structural comparison of the major envelope glycoproteins (gp70) from 35 different murine type C viruses and free gp70 expressed at various anatomical sites in the mouse showed that the gp70s are polymorphic products of a large multi-gene family encoding viral and differentiation antigens. Different proviruses are expressed in cells following distinct pathways of differentiation. When the various gp70s are grouped according to primary structure they fall naturally into viral host range classes, confirming the suspicion that C-type viral tropism is largely determined by the nature of the gp70 product expressed.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Tooze, J. The Molecular Biology of Tumour Viruses (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1973).
    Google Scholar
  2. Aoki, T. et al. J. natn. Cancer Inst. 52, 1189–1197 (1974).
    Article CAS Google Scholar
  3. Fenner, R. et al. The Biology of Animal Viruses 2nd ed (Academic, New York, 1973).
    Google Scholar
  4. Stockert, E., Old, L. J. & Boyse, E. A. J. exp. Med. 133, 1334–1355 (1971).
    Article CAS PubMed PubMed Central Google Scholar
  5. Rowe, W. P. Cancer Res. 33, 3061–3068 (1973).
    CAS PubMed Google Scholar
  6. Strand, M., Lilly, F. & August, J. T. Proc. natn. Acad. Sci. U.S.A. 71, 3682–3686 (1974).
    Article ADS CAS Google Scholar
  7. Lerner, R. A. et al. J. exp. Med. 143, 151–166 (1976).
    Article CAS PubMed Google Scholar
  8. Tung, J. S. et al. J. exp. Med. 141, 198–205 (1975).
    Article CAS PubMed Google Scholar
  9. Del Villano, B. C. et al. J. exp. Med. 141, 172–187 (1975).
    Article CAS Google Scholar
  10. Boyse, E. A. & Old, L. J. A. Rev. Genetics 3, 269–290 (1969).
    Article Google Scholar
  11. Strand, M. & August, J. T. J. biol. Chem. 248, 5627–5633 (1973).
    CAS PubMed Google Scholar
  12. August, J. T. et al. Virology 60, 595–601 (1974).
    Article CAS PubMed Google Scholar
  13. Greenwood, F. C., Hunter, W. M. & Glover, J. S. Biochem. J. 89, 114–123 (1963).
    Article CAS PubMed PubMed Central Google Scholar
  14. Laemmli, U. K. Nature 227, 680–685 (1970).
    Article ADS CAS PubMed Google Scholar
  15. Gibson, W. Virology 62, 319–336 (1974).
    Article CAS PubMed Google Scholar
  16. Marquart, H., Gilden, R. V. & Oroszlan, S. Biochemistry 16, 710–717 (1977).
    Article Google Scholar
  17. Troxler, D., Parks, W., Vass, W. & Scolnick, E. Virology 76, 602–615 (1977).
    Article CAS PubMed Google Scholar
  18. Bryant, M. L. & Klement, V. Virology 73, 532–536 (1976).
    Article CAS PubMed Google Scholar
  19. Kennel, S. J. J. biol. Chem. 251, 6197–6204 (1976).
    CAS PubMed Google Scholar
  20. Porath, J. & Kristiansen, T. in The Proteins (eds H. Neurath and R. Hill), 1, 95–178 (Academic, New York, 1975).
    Book Google Scholar
  21. Rasheed, S., Gardner, M. B. & Chan, E. J. Virol. 19, 13–18 (1976).
    CAS PubMed PubMed Central Google Scholar
  22. Hartley, J. W. & Rowe, W. P. J. Virol. 19, 19–25 (1976).
    CAS PubMed PubMed Central Google Scholar
  23. Hino, S., Stephenson, J. R. & Aaronson, S. A. J. Virol. 18, 933–941 (1976).
    CAS PubMed PubMed Central Google Scholar
  24. Gardner, M. B. et al. Cancer Res. 36, 574–581 (1976).
    CAS PubMed Google Scholar
  25. Del Villano, B. C. & Lerner, R. A. Nature 259, 497–499 (1976).
    Article ADS CAS PubMed Google Scholar
  26. Hood, L., Elgin, S. R. & Campbell, J. H. A. Rev. Genetics 9, 305–353 (1975).
    Article CAS Google Scholar
  27. Chattopadhyay, S. K. et al. Cold Spring Harb. Symp. quant. Biol. 39, 1085–1101 (1974).
    Article Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037
    J. H. Elder, F. C. Jensen, M. L. Bryant & R. A. Lerner

Authors

  1. J. H. Elder
    You can also search for this author inPubMed Google Scholar
  2. F. C. Jensen
    You can also search for this author inPubMed Google Scholar
  3. M. L. Bryant
    You can also search for this author inPubMed Google Scholar
  4. R. A. Lerner
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Elder, J., Jensen, F., Bryant, M. et al. Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family.Nature 267, 23–28 (1977). https://doi.org/10.1038/267023a0

Download citation