Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice (original) (raw)

Nature volume 268, pages 67–68 (1977)Cite this article

Abstract

SEVERAL reports1–6 have indicated that lymphocytic choriomeningitis virus (LCMV) infection of mice or cultured cells is not associated with interferon production. But, as was found later7 the methods used may not have been sensitive enough to detect interferon in tissues of virus infected animals. In contrast to these earlier observations, mice acutely infected with M-P virus, a virus closely related to LCMV (ref. 8), have been reported to produce interferon9. We observed a more intense and prolonged interferon response to a virus inducer in nude athymic mice (Fig. 1) as others10 have with synthetic double-stranded nucleic acids. Therefore, it seemed reasonable to study LCMV infection of nude animals carefully for interferon production in serum and infected organs. Parental strains and nude heterozygotes (Nu/+) were studied as well as the homozygous nude (Nu/Nu) animals. The results presented here indicate that interferon is made in greater quantity and persists longer during infection of Nu/Nu than of parental and Nu/+ mice.

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Authors and Affiliations

  1. Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, 94305
    THOMAS C. MERIGAN
  2. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037
    MICHAEL B. A. OLDSTONE & RAYMOND M. WELSH

Authors

  1. THOMAS C. MERIGAN
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  2. MICHAEL B. A. OLDSTONE
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  3. RAYMOND M. WELSH
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MERIGAN, T., OLDSTONE, M. & WELSH, R. Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice.Nature 268, 67–68 (1977). https://doi.org/10.1038/268067a0

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