Androgenetic origin of hydatidiform mole (original) (raw)

Nature volume 268, pages 633–634 (1977)Cite this article

Abstract

CLASSIC hydatidiform mole is the product of an abnormal pregnancy with grossly swollen chorionic villi, but without an embryo, cord or amniotic membrane. Histologically, the villi are characterised by advanced hyperplasia and anaplasia of the trophoblast, oedema of the stroma and the absence of foetal capillaries1. A malignant change to invasive mole or choriocarcinoma is frequent. The karyotype of the mole is predominantly, if not exclusively, 46,XX. We have made a cytogenetic study of the origin of hydatidiform mole and found that it receives only paternal chromosomes and is therefore androgenetic in origin.

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Author notes

  1. TADASHI KAJII
    Present address: Genetic and Endocrine Unit, Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York, 13210

Authors and Affiliations

  1. Laboratory of Embryology and Cytogenetics, University Clinic of Gynaecology and Obstetrics, Geneva, Switzerland
    TADASHI KAJII
  2. Department of Obstetrics and Gynaecology, Hiroshima University School of Medicine, Hiroshima, Japan
    Koso OHAMA

Authors

  1. TADASHI KAJII
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  2. Koso OHAMA
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KAJII, T., OHAMA, K. Androgenetic origin of hydatidiform mole.Nature 268, 633–634 (1977). https://doi.org/10.1038/268633a0

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