Cortisol levels during human aging predict hippocampal atrophy and memory deficits (original) (raw)

References

  1. McEwen, B.S. Protective and damaging effects of stress mediators. New Engl. J. Med. 238, 171–179 (1998)
    Article Google Scholar
  2. Jacobson, L. & Sapolsky, R.M. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenal axis. Endo. Rev. 12, 118–134 (1991)
    Article CAS Google Scholar
  3. Brindley, D.N. & Rolland, Y. Possible connections between stress, diabetes, obesity, hypertension and altered lipoprotein metabolism that may result in atherosclerosis. Clin. Sci. 77, 453–461 (1989)
    Article CAS Google Scholar
  4. Sapolsky, R. Stress, the aging brain, and the mechanisms of neuron death. (MIT Press, Cambridge, 1992)
    Google Scholar
  5. Landfield, P., Baskin, R. K. & Pitler, T. A. Brain-aging correlates: Retardation by hormonal-pharmacological treatments. Science 214, 581– 583 (1981)
    Article CAS Google Scholar
  6. Landfield, P., Waymire, J. & Lynch, G. Hippocampal aging and adrenocorticoids: Quantitative correlations. Science 202, 1098–1102 (1978)
    Article CAS Google Scholar
  7. Issa, A., Gauthier, S. & Meaney, M. J. Hypothalamic-pituitary-adrenal activity in aged cognitively impaired and cognitively unimpaired aged rats. J. Neurosci. 10, 3247 –3254 (1990)
    Article CAS Google Scholar
  8. Squire, L. R. Memory and the hippocampus : A synthesis from findings with rats, monkeys, and humans . Psychol. Rev. 99, 195– 231 (1992)
    Article CAS Google Scholar
  9. Starkman, M. N., Gebarski, S. S., Berent, S. & Schteingart, D. E. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol. Psychiatry 32, 756–765 (1992)
    Article CAS Google Scholar
  10. Davis, K. L. et al. Cortisol and Alzheimer's disease, I : Basal studies. Am. J. Psychiatry 143, 300–305 (1986)
    Article CAS Google Scholar
  11. Lupien, S. J. et al. Longitudinal study of basal cortisol levels in healthy elderly subjects : Evidence for sub-groups. Neurobiol. Aging 17, 95– 105 (1995)
    Article Google Scholar
  12. Lupien, S. J. . & McEwen, B. S. The acute effects of corticosteroids on cognition: Integration of animal and human model studies. Brain Res. Rev. 24, 1–27 (1997)
    Article CAS Google Scholar
  13. Wolkowitz, O. M., Reus, V. I., Canick, J., Levin, B. & Lupien, S.J. Glucocorticoid medication, memory and steroid psychosis in medical illness. Ann. NY Acad. Sci. 823, 81–96 (1997)
    Article CAS Google Scholar
  14. Lupien, S. et al. Basal cortisol levels and cognitive deficits in human aging, J. Neurosci . 14, 2893–2903 (1994)
    Article CAS Google Scholar
  15. Scolville, W. B. & Milner, B. Hippocampal damage and memory dysfunction . J. Neurol. Psychiatry 20, 11– 21 (1957)
    Article Google Scholar
  16. O'Keefe, J. & Nadel, L. The Hippocampus as a Cognitive Map (Oxford, Clarendon, 1978)
    Google Scholar
  17. de Leon, M. J. et al. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol. Aging 18, 1–11 (1997)
    Article CAS Google Scholar
  18. de Leon, M. et al. Abnormal cortisol response in Alzheimer's disease linked to hippocampal atrophy. Lancet 2, 391–392 (1988)
    Article CAS Google Scholar
  19. Fischette, C. T., Komisurak, B. R., Ediner, H. M., Feder, H. H. & Siegal, A. Differential fornix ablations and the circadian rhythmicity of adrenal corticosterone secretion. Brain Res. 195, 373–380 (1980)
    Article CAS Google Scholar
  20. DeKloet, E. R. Brain corticosteroid receptor balance and homeostatic control. Front. Neuroendocrinol. 12, 95–123 (1991)
    Google Scholar
  21. Sapolsky, R. M., Krey, L. C. & McEwen, B. S. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Endo. Rev. 7, 284– 301 (1986)
    Article CAS Google Scholar
  22. Joels, M. Steroid hormones and excitability in the mammalian brain. Front. Neuroendocrinol. 18, 495–4498 (1997)
    Article Google Scholar
  23. Sloviter, R. et al. Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy . Science 243, 535–538 (1989)
    Article CAS Google Scholar
  24. Reul, J. M. H. M. & De Kloet, E. R. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117, 2505–2512 (1985)
    Article CAS Google Scholar
  25. Kerr, D. S., Campbell, L. W., Hao, S. -Y. & Landfield, P. W. Corticosteroid modulation of hippocampal potentials: Increased effect with aging. Science 245, 1505–1509 (1989)
    Article CAS Google Scholar
  26. Diamond, D. M., Bennett, M. C., Fleshner, M. & Rose, G. M. Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus 2, 421–430 (1992)
    Article CAS Google Scholar
  27. Joels, M. & De Kloet, E. R. Effect of glucocorticoids and norepinephrine on excitability in the hippocampus. Science 245, 1502–1504 (1989)
    Article CAS Google Scholar
  28. Magarinos, A. M., McEwen, B. S., Flugge, G. & Fuchs, E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J. Neurosci. 16 , 3534–3540 (1996)
    Article CAS Google Scholar
  29. Gould, E., Tanapat, P., McEwen, B. S., Flugge, G. & Fuchs, E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. USA 95, 3168–3171 (1998)
    Article CAS Google Scholar
  30. Landfield, P. W. & Elridge, J. C. Evolving aspects of the glucocorticoid hypothesis of brain aging: Hormonal modulation of neuronal calcium homeostasis . Neurobiol. Aging 15, 579– 588 (1994)
    Article CAS Google Scholar

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