The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis (original) (raw)

• Fearon, E. R. et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247, 49–56 (1990).
  Article ADS CAS Google Scholar
• Fearon, E. R. DCC: is there a connection between tumorigenesis and cell guidance molecules? Biochim. Biophys. Acta 1288, M17–M23 (1996).
  PubMed Google Scholar
• Tanaka, K. et al. Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18. Nature 349, 340–342 (1991).
  Article ADS CAS Google Scholar
• Klingelhutz, A. J., Hedrick, L., Cho, K. R. & McDougall, J. K. The DCC gene suppresses the malignant phenotype of transformed human epithelial cells. Oncogene 10, 1581–1586 (1995).
  CAS PubMed Google Scholar
• Fazeli, A. et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386, 796–804 (1997).
  Article ADS CAS Google Scholar
• Serafini, T. et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001–1014 (1996).
  Article CAS Google Scholar
• Kennedy, T. E., Serafini, T., de la Torre, J. R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425–435 (1994).
  Article CAS Google Scholar
• Keino-Masu, K. et al. Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell 87, 175–185 (1996).
  Article CAS Google Scholar
• Rabizaedh, S. et al. Induction of apoptosis by the low-affinity NGF receptor. Science 261, 345–348 (1993).
  Article ADS Google Scholar
• Rabizadeh, S. & Bredesen, D. E. Is p75NGFR involved in developmental neural cell death? Dev. Neurosci. 16, 207–211 (1994).
  Article CAS Google Scholar
• Bredesen, D. E. & Rabizadeh, S. p75NTR and apoptosis: Trk-dependent and Trk-independent effects. Trends Neurosci. 20, 287–290 (1997).
  Article CAS Google Scholar
• Bredesen, D. E. et al. p75NTR and the concept of cellular dependence: seeing how the other half die. Cell Death Differ. 5, 365–371 (1998).
  Article CAS Google Scholar
• Ellerby, L. M. et al. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J. Neurochem.(in the press).
• Ellerby, H. M. et al. Establishment of a cell-free system for neuronal apoptosis: comparison of pre-mitochondrial, mitochondrial, and post-mitochondrial phases. J. Neurosci. 17, 6165–6178 (1997).
  Article CAS Google Scholar
• Thornberry, N. A. et al. Acombinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272, 17907–17911 (1997).
  Article CAS Google Scholar
• Yang, F. et al. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am. J. Pathol. 152, 379–389 (1998).
  CAS PubMed PubMed Central Google Scholar
• Cho, K. R. & Fearon, E. R. DCC: linking tumor suppressor genes and altered cell surface interactions in cancer? Curr. Opin. Genet. Dev. 5, 72–78 (1995).
  Article CAS Google Scholar
• Kern, S. E.et al. Allelic loss in colorectal carcinomas. J. Am. Med. Assoc. 261, 3099–3103 (1989).
  Article CAS Google Scholar
• Bennett, K. L. et al. Deleted in colorectal carcinoma (DCC) binds heparin via its fifth fibronectin type III domain. J. Biol. Chem. 272, 26940–26946 (1997).
  Article CAS Google Scholar
• Pflug, B. R., Onoda, M., Lynch, J. H. & Djakiew, D. Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastic prostate tumor cell lines. Cancer Res. 52, 5403–5406 (1992).
  CAS PubMed Google Scholar
• Bredesen, D. E. in Apoptosis II: The Molecular Basis of Apoptosis in Diseas 397–421 (eds Tomei, L. D. & Cope, F. O.) (Cold Spring Harb. Lab. Press, Plainview, New York, (1994).
  Google Scholar
• Mehlen, P., Kretz Remy, C., Preville, X. & Arrigo, A.-P. Human hsp27, Drosophila hsp27 and human αB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFα-induced cell death. EMBO J. 15, 2695–2706 (1996).
  Article CAS Google Scholar
• Ruan, Y., Camerini, D., Rabizadeh, S. & Bredesen, D. E. Expression of CD40 induces neural apoptosis. J. Neurosci. Res. 50, 383–390 (1997).
  Article CAS Google Scholar
• Mehlen, P. et al. Constitutive expression of either human hsp27, Drosophila hsp27 or human α-B crystallin confers resistance to tumor necrosis factor- and oxidative stress-induced cytotoxity in stably transfected murine L929 fibroblasts. J. Immunol. 154, 363–374 (1995).
  CAS PubMed Google Scholar
• Mehlen, P., Coronas, V., Ljubic, V., Jourdan, F. & Arrigo, A.-P. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. Cell Death Differ.(in the press).
• Reale, M. A. et al. Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Cancer Res. 54, 4493–4501 (1994).
  CAS PubMed Google Scholar
• Rabizadeh, S. et al. Mechanism of neurotrophin dependence: requirement for a novel type of domain. Cell(submitted).
• Jordan, M., Schallhorn, A. & Wurm, F. M. Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate percipitate formation. Nucleic Acids Res. 24, 596–601 (1996).
  Article CAS Google Scholar
• Stennicke, H. R. & Salvesen, G. S. Biochemical characteristics of caspases-3, -6, -7, and -8. J. Biol. Chem. 272, 25719–25723 (1997).
  Article CAS Google Scholar