T antigen is bound to a host protein in SY40-transformed cells (original) (raw)
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- Published: 15 March 1979
Nature volume 278, pages 261–263 (1979)Cite this article
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Abstract
THE early region of the small DNA tumour virus, simian virus 40 (SV40), is known to code for at least two polypeptides, the t and T antigens (‘small t’ and ‘large T’). Both these polypeptides are expressed in cells transformed by the virus1–4, and the T antigen has been shown to be essential for both the initiation and maintenance of the transformed state5–9. We therefore need to know how this T protein interacts with components of the host cell in order to understand the mechanism of SV40-induced transformation. We report here that the T antigen in a line of SV40-transformed mouse cells forms an oligomeric complex with a specific cell coded protein.
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Author notes
- D. P. LANE
Present address: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
Authors and Affiliations
- Department of Zoology, Imperial College, London, SW7, UK
D. P. LANE - Department of Molecular Virology, Imperial Cancer Research Fund, London, WC2, UK
L. V. CRAWFORD
Authors
- D. P. LANE
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LANE, D., CRAWFORD, L. T antigen is bound to a host protein in SY40-transformed cells.Nature 278, 261–263 (1979). https://doi.org/10.1038/278261a0
- Received: 03 November 1978
- Accepted: 30 January 1979
- Issue Date: 15 March 1979
- DOI: https://doi.org/10.1038/278261a0
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