Immunisation against heterologous type II collagen induces arthritis in mice (original) (raw)

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• Published: 14 February 1980

Nature volume 283, pages 666–668 (1980)Cite this article

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Abstract

The induction of polyarthritis in rats by intradermal immunisation with homologous or heterologous type II collagen in complete or incomplete Freund's adjuvant was reported recently by Trentham _et al._1. We have now produced a similar disease in certain strains of mice.

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References

1. Trentham, D. E., Townes, A. S. & Kang, A. H. J. exp. Med. 146, 857–868 (1977).
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2. Trentham, D. E., Dynesius, R. A. & David, J. R. J. clin. Invest. 62, 359–366 (1978).
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3. Nowack, H., Hahn, E. & Timpl, R. Immunology 29, 621–628 (1975).
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5. Trentham, D. E., Townes, A. S. & Kang, A. H. J. clin. Invest. 61, 89–96 (1978).
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Authors and Affiliations

1. Departments of Protein Chemistry and Pathology, Wellcome Research Laboratories, Beckenham, Kent, UK
   J. S. Courtenay, Margaret J. Dallman, A. D. Dayan, Angela Martin & Betty Mosedale

Authors

1. J. S. Courtenay
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2. Margaret J. Dallman
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3. A. D. Dayan
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4. Angela Martin
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5. Betty Mosedale
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Courtenay, J., Dallman, M., Dayan, A. et al. Immunisation against heterologous type II collagen induces arthritis in mice.Nature 283, 666–668 (1980). https://doi.org/10.1038/283666a0

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• Received: 03 October 1979
• Accepted: 19 November 1979
• Issue Date: 14 February 1980
• DOI: https://doi.org/10.1038/283666a0

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