Comparison of white pock (h) mutants of monkeypox virus with parental monkeypox and with variola-like viruses isolated from animals (original) (raw)

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• Published: 03 July 1980

Nature volume 286, pages 29–32 (1980)Cite this article

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Abstract

Monkeypox mutants arising spontaneously or after serial, high multiplicity passage were characterized phenotypically and by restriction endonuclease mapping. Some resemble ‘whitepox’ and variola viruses in several of the markers tested but all are distinguishable phenotypically from these. None resembles ‘whitepox’ viruses in genome structure although near-terminal deletions or symmetrical, terminal rearrangements, relative to parental monkeypox, occurred. ‘Whitepox’ viruses isolated from animals closely resemble variola in both phenotype and genome structure.

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References

1. Von Magnus, P., Andersen, E. K., Petersen, K. B. & Birch-Andersen, A. Acta path. microb. Scand. 46, 156–176 (1959).
   Article Google Scholar
2. Breman, J. G. et al. Bull. Wld Hlth Org. (in the press).
3. Marennikova, S. S. & Shelukhina, E. M. Nature 276, 291–292 (1978).
   Article ADS CAS Google Scholar
4. Marennikova, S. S., Shelukhina, E. M., Maltseva, N. N. & Matsevich, G. R. Intervirology 11, 333–340 (1979).
   Article CAS Google Scholar
5. Wittek, R. et al. J. Virol. 23, 669–678 (1977).
   CAS PubMed PubMed Central Google Scholar
6. Mackett, M. & Archard, L. C. J. gen. Virol. 45, 683–701 (1979).
   Article CAS Google Scholar
7. Bedson, H. S. & Dumbell, K. R. J. Hyg., Camb. 59, 457–469 (1961).
   Article CAS Google Scholar
8. Siim, J. C. Acta med. scand. Suppl. 234, 304–316 (1949).
   Google Scholar
9. Huq, F. thesis, Univ. London (1972).
10. Dumbell, K. R. Lancet, ii, 585 (1974).
    Article Google Scholar
11. Marennikova, S. S., Gurvich, E. B. & Shelukhina, E. M. Arch. ges. Virusforsch. 33, 201–210 (1971).
    Article CAS Google Scholar
12. Archard, L. C. & Mackett, M. J. gen. Virol. 45, 51–63 (1979).
    Article CAS Google Scholar
13. Wittek, R., Müller, H. K., Menna, A. & Wyler, R. FEBS Lett. 90, 41–46 (1978).
    Article CAS Google Scholar
14. Esposito, J. J., Obijeski, J. F. & Nakano, J. H. Virology 89, 53–66 (1978).
    Article CAS Google Scholar
15. Wittek, R. et al. J. Virol. 28, 171–181 (1978).
    CAS PubMed PubMed Central Google Scholar
16. Archard, L. C. J. gen. Virol. 42, 223–229 (1979).
    Article CAS Google Scholar
17. McFadden, G. & Dales, S. Cell 18, 101–108 (1979).
    Article CAS Google Scholar

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Authors and Affiliations

1. Department of Virology, St Mary's Hospital Medical School, London, W2 1PG, UK
   K. R. Dumbell & L. C. Archard

Authors

1. K. R. Dumbell
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2. L. C. Archard
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Dumbell, K., Archard, L. Comparison of white pock (h) mutants of monkeypox virus with parental monkeypox and with variola-like viruses isolated from animals.Nature 286, 29–32 (1980). https://doi.org/10.1038/286029a0

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• Received: 09 April 1980
• Accepted: 14 May 1980
• Issue Date: 03 July 1980
• DOI: https://doi.org/10.1038/286029a0

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