Mutations affecting segment number and polarity in Drosophila (original) (raw)
- Article
- Published: 30 October 1980
Nature volume 287, pages 795–801 (1980)Cite this article
- 34k Accesses
- 3356 Citations
- 175 Altmetric
- Metrics details
Abstract
In systematic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental pattern of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Lohs-Schardin, M., Cremer, C. & Nüsslein-Volhard, C. Devl. Biol. 73, 239–255 (1979).
Article CAS Google Scholar - Wieschaus, E. & Gehring, W. Devl. Biol. 50, 249–263 (1976).
Article CAS Google Scholar - Nüsslein-Volhard, C. in Determinants of Spatial Organisation (eds Subtelney, S. & Konigsberg, I. R.) 185–211 (Academic, New York, 1979).
Book Google Scholar - Sander, K. Adv. Insect Physiol. 12, 125–238 (1976).
Article Google Scholar - Lewis, E. B. Nature 276, 565–570 (1978).
Article ADS CAS Google Scholar - Garcia-Bellido, A. Am. Zool. 17, 613–629 (1977).
Article Google Scholar - Szabad, J., Schüpbach, T. & Wieschaus, E. Devl. Biol. 73, 256–271 (1979).
Article CAS Google Scholar - Counce, S. Z. Induktive Abstammungs-Vererbungslehre 87, 462–81 (1958).
- Sharma, R. P. & Chopra, V. L. Devl Biol. 48, 461–465 (1976).
Article CAS Google Scholar - Lawrence, P. A. & Morata, G. Devl Biol. 50, 321–337 (1976).
Article CAS Google Scholar - Kornberg, T., in preparation.
- Gloor, H. Arch. Julius-Klaus-Stift. VererbForsch 25, 38–44 (1950).
Google Scholar - Meinhardt, H. J. Cell Sci. 23, 117–139 (1977).
Google Scholar - Bryant, P. J. Ciba Fdn Symp. 29, 71–93 (1975).
Google Scholar - Wright, D. & Lawrence, P. A., in preparation.
- Lawrence, P. A. in Developmental Systems: Insects (eds Counce, S. & Waddington, C. H.) 157–209 (Academic, London, 1973).
Google Scholar - Jürgens, G. & Gateff, E. Wilhelm Roux Arch. 186, 1–25 (1979).
Article Google Scholar - Meinhardt, H. & Gierer, A. J. Cell. Sci. 15, 321–346 (1974).
CAS PubMed Google Scholar - Kaufmann, S. A., Shymko, R. M. & Trabert, K. Science 199, 259–270 (1978).
Article ADS Google Scholar - Lindsley, D. & Grell, E. H. Genetic Variations of Drosophila melanogaster (Carnegie, Washington, 1968).
Google Scholar - Wright, T. R. F. Drosoph. Inf. Serv. 45, 140 (1970).
Google Scholar - Vander Meer, J. Drosoph. Inf. Serv. 52, 160 (1977).
Google Scholar
Author information
Authors and Affiliations
- European Molecular Biology Laboratory, PO Box 10.2209, 69, Heidelberg, FRG
Christiane Nüsslein-Volhard & Eric Wieschaus
Authors
- Christiane Nüsslein-Volhard
You can also search for this author inPubMed Google Scholar - Eric Wieschaus
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Nüsslein-Volhard, C., Wieschaus, E. Mutations affecting segment number and polarity in Drosophila.Nature 287, 795–801 (1980). https://doi.org/10.1038/287795a0
- Received: 26 June 1980
- Accepted: 29 August 1980
- Issue Date: 30 October 1980
- DOI: https://doi.org/10.1038/287795a0