Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein–Barr virus (original) (raw)
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- Published: 03 December 1981
Nature volume 294, pages 458–460 (1981)Cite this article
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Abstract
Epstein–Barr virus (EBV) transforms human B lymphocytes in vitro and is associated with two human lymphoproliferative diseases, Burkitt's lymphoma and infectious mononucleosis. In contrast to the lymphoma, infectious mononucleosis is self-limiting and the finding by Svedmyr and Jondal1 of cytotoxic T lymphocytes specific for EBV-transformed cell lines in mononucleosis patients' blood during the acute phase suggests that this self-limitation results, in part, from the cell-mediated immune response of the host. These workers termed the structure expressed on EBV-transformed cells and which was recognized by specific, cytotoxic T cells, LYDMA (lymphocyte determined membrane antigen). It has also been shown that with appropriate education in culture, cytotoxic T cells from healthy donors specifically kill autochthonous, EBV-transformed cell lines2. These target cells generally do not produce virus and bear no virion-associated antigens. We have now isolated monoclonal antibodies which detect antigenic determinants unique to the surfaces of EBV-transformed cells but are not associated with virus production. Quantitative assays for these determinants indicate that they are expressed strongly on cells transformed in vitro by EBV but are expressed at intermediate or undetectable levels on cell lines established from patients with Burkitt's lymphoma. These antigenic determinants may be among those recognized by autochthonous, cytotoxic T cells specific for EBV-transformed cell lines, and if they are, their diminished expression on tumour-derived cells may reflect a selective advantage in vivo for those tumour cells.
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Author notes
- Chris Kintner
Present address: Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA
Authors and Affiliations
- The McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin, 53706, USA
Chris Kintner & Bill Sugden
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- Chris Kintner
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Kintner, C., Sugden, B. Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein–Barr virus.Nature 294, 458–460 (1981). https://doi.org/10.1038/294458a0
- Received: 29 July 1981
- Accepted: 13 October 1981
- Issue Date: 03 December 1981
- DOI: https://doi.org/10.1038/294458a0