Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey (original) (raw)

Nature volume 295, pages 327–329 (1982)Cite this article

Abstract

Leukotriene C4 (LTC4) and its metabolites LTD4 and LTE4 (Fig. 1) have been identified as the major active constituents of slow-reacting substance of anaphylaxis (SRS-A)1–3. Leukotrienes C4, D4 and E4 have rapidly gained recognition as bronchoconstrictors of hitherto unsurpassed potency in the guinea pig in vivo and _in vitro_4–7 as well as acting as oedema-forming substances in guinea pig3,5,7 and hamster8. Here we report that LTC4 is also a prominent bronchoconstrictor in the monkey; it increases transpulmonary pressure in the anaesthetized animal, mainly by decreasing pulmonary dynamic compliance, and it contracts isolated tracheal spiral tissue. Furthermore, LTC4 causes transient pulmonary and systemic hypertension, followed by a prolonged hypotensive period associated with decreased cardiac output, haemoconcentration and reduction in the number of circulating leukocytes. These in vivo findings in a primate imply that leukotrienes may also cause important alterations of cardiovascular and pulmonary function in man.

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References

  1. Samuelsson, B., Hammarström, S., Murphy, R. C. & Borgeat, P. Allergy 35, 375–381 (1980).
    Article CAS Google Scholar
  2. Samuelsson, B. & Hammarström, S. Prostaglandins 19, 645–648 (1980).
    Article CAS Google Scholar
  3. Lewis, R. A., Drazen, J. M., Austen, K. F., Clark, D. A. & Corey, E. J. Biochem. biophys. Res. Commun. 96, 271–277 (1980).
    Article CAS Google Scholar
  4. Hedqvist, P., Dahlén, S.-E., Gustafsson, L., Hammarström, S. & Samuelsson, B. Acta physiol. scand. 110, 331–333 (1980).
    Article CAS Google Scholar
  5. Drazen, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 77, 4354–4358 (1980).
    Article ADS CAS Google Scholar
  6. Welton, A. F., Crowley, H. J., Miller, D. A. & Yaremko, B. Prostaglandins 21, 287–296 (1981).
    Article CAS Google Scholar
  7. Piper, P. J. et al. in SRS-A and Leukotrienes (ed. Piper, P. J.) 81–99 (Wiley, Chichester, 1981).
    Google Scholar
  8. Dahlén, S.-E. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3887–3891 (1981).
    Article ADS Google Scholar
  9. Smedegård, G., Revenäs, B., Lundberg, C. & Arfors, K.-E. Acta physiol. scand. 111, 239–247 (1981).
    Article Google Scholar
  10. Revenäs, B., Smedegård, G. & Arfors, K.-E. Acta anaesth. scand. 23, 278–284 (1979).
    Article Google Scholar
  11. Murphy, R. C., Hammarström, S. & Samuelsson, B. Proc. natn. Acad. Sci. U.S.A. 76, 4275–4279 (1979).
    Article ADS CAS Google Scholar
  12. Levi, R. in Advances in Prostaglandin and Thromboxane Research (eds Samuelsson, B. & Paoletti, R.) (Raven, New York, in the press).
  13. Piper, P. J. in Advances in Prostaglandin and Thromboxane Research (eds Samuelsson, B. & Paoletti, R.) (Raven, New York, in the press).
  14. Hammarström, S., Biochem. biophys. Res. Commun. 101, 1109–1115 (1981).
    Article Google Scholar
  15. Hammarström, S. in Advances in Prostaglandin and Thromboxane Research (eds Samuelsson, B. & Paoletti, R.) (Raven, New York, in the press).
  16. Hedqvist, P., Dahlén, S.-E. & Björk, J. in Advances in Prostaglandin and Thromboxane Research (eds Samuelsson, B. & Paoletti, R.) (Raven, New York, in the press).
  17. Drazen, J. M. & Austen, K. F. J. clin. Invest. 53, 1679–1685 (1974).
    Article CAS Google Scholar
  18. Dahlén, S.-E., Hedqvist, P. & Hammarström, S. Acta physiol. scand. (in the press).
  19. Dahlén, S.-E., Hedqvist, P., Hammarström, S. & Samuelsson, B. Nature 288, 484–486 (1980).
    Article ADS Google Scholar
  20. Hanna, C. J., Bach, M. K., Pare, P. D. & Schellenberg, R. R. Nature 290, 343–344 (1981).
    Article ADS CAS Google Scholar

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Authors and Affiliations

  1. Department of Experimental Medicine, Pharmacia AB, Uppsala, Sweden
    Göran Smedegård & Björn Revenäs
  2. Department of Experimental Allergy Research, Pharmacia AB, Uppsala, Sweden
    Göran Smedegård
  3. Department of Physiology, Karolinska Institutet, Stockholm, Sweden
    Per Hedqvist & Sven-Erik Dahlén
  4. Department of Chemistry, Karolinska Institutet, Stockholm, Sweden
    Sven Hammarström & Bengt Samuelsson

Authors

  1. Göran Smedegård
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  2. Per Hedqvist
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  3. Sven-Erik Dahlén
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  4. Björn Revenäs
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  5. Sven Hammarström
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  6. Bengt Samuelsson
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Smedegård, G., Hedqvist, P., Dahlén, SE. et al. Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey.Nature 295, 327–329 (1982). https://doi.org/10.1038/295327a0

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