Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis (original) (raw)
- Letter
- Published: 06 May 1982
Nature volume 297, pages 70–72 (1982)Cite this article
- 333 Accesses
- 220 Citations
- Metrics details
Abstract
Among the heterogeneous population of antibodies specifically induced during many acute viral infections, those having virus-neutralizing activity in vitro are generally considered to be most important for recovery and immunity to reinfection. Similarly, the ability to stimulate production of circulating neutralizing (NT) antibodies is a major criterion for evaluating the immunoprophylactic potential of many antiviral vaccines1. Although there is obviously an association between NT antibody induction and host resistance, we present here data which indicate that other virus-specific antibodies lacking NT function may be equally important in conferring protective immunity to alphaviruses. We used monoclonal antibodies against Sindbis virus (SV) to demonstrate that passive protection of SV-infected mice from fatal paralytic central nervous system (CNS) disease may be mediated not only by antibodies which neutralize the infectivity of extracellular virus particles but also by those lacking this capacity, which react preferentially with virus-infected cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Scherer, W. F. et al. Am. J. trop. Med. Hyg. 29, 1359–1381 (1980).
Article Google Scholar - Dalrymple, J. M., Schlesinger, S. & Russell, P. K. Virology 69, 93–103 (1976).
Article CAS Google Scholar - Porterfield, J. S. in The Togaviruses: Biology, Structure, Replication (ed. Schlensinger, R. W.) 13–46 (Academic, New York, 1980).
Book Google Scholar - Dalrymple, J., Cole, G., Jahrling, P., Johnson, E. & Harrison, S. Abstr. 5th int. Congr. Virol., 380 (1981).
- Griffin, D. E. & Johnson, R. I. J. Immun. 118, 1070–1075 (1977).
CAS PubMed Google Scholar - Kennett, R. H., McKearn, T. J. & Bechtol, K. B. (eds) Monoclonal Antibodies 365–367 (Plenum, New York, 1980).
Google Scholar - Zollinger, W. D., Dalrymple, J. M. & Artenstein, M. S. J. Immun. 117, 1788–1798 (1976).
CAS PubMed Google Scholar - Monath, T. P. in Manual of Clinical Immunology (eds Rose, N. R. & Friedman, H.) 456–462 (American Society for Microbiology, Washington, 1976).
Google Scholar - Scheefers, H., Scheefers-Borchel, U., Edwards, J. & Brown, D. T. Proc. natn. Acad. Sci. U.S.A. 77, 7277–7281 (1980).
Article ADS CAS Google Scholar - Spiegelberg, H. L. Adv. Immun. 19, 259–294 (1974).
Article CAS Google Scholar - Hirsch, R. L., Griffin, D. E. & Winkelstein, J. A. J. Immun. 121, 1276–1278 (1978).
CAS PubMed Google Scholar - Hirsch, R. L., Griffin, D. E. & Winkelstein, J. A. Infect. Immunity 30, 899–901 (1980).
CAS Google Scholar - Schlesinger, M. J. & Kääriäinen, L. in The Togaviruses: Biology, Structure, Replication (ed. Schlesinger, R. W.) 371–392 (Academic, New York, 1980).
Book Google Scholar - Peck, R., Brown, A. & Wust, C. J. J. Immun. 123, 1763–1766 (1979).
CAS PubMed Google Scholar - Hapel, A. J., Bablanian, R. & Cole, G. A. J. Immun. 124, 1990–1996 (1980).
CAS PubMed Google Scholar
Author information
Authors and Affiliations
- Department of Microbiology, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA
A. L. Schmaljohn & G. A. Cole - Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, 21701, USA
E. D. Johnson & J. M. Dalrymple
Authors
- A. L. Schmaljohn
You can also search for this author inPubMed Google Scholar - E. D. Johnson
You can also search for this author inPubMed Google Scholar - J. M. Dalrymple
You can also search for this author inPubMed Google Scholar - G. A. Cole
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Schmaljohn, A., Johnson, E., Dalrymple, J. et al. Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis.Nature 297, 70–72 (1982). https://doi.org/10.1038/297070a0
- Received: 23 November 1981
- Accepted: 05 March 1982
- Issue Date: 06 May 1982
- DOI: https://doi.org/10.1038/297070a0