Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription (original) (raw)

• Heldin, C. H., Miyazono, K. & ten Dijke, P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465– 471 (1997).
  Article ADS CAS Google Scholar
• Lagna, G., Hata, A., Hemmati-Brivanlou, A. & Massagué, J. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383, 832–836 (1996).
  Article ADS CAS Google Scholar
• Zhang, Y., Feng, X.-H., Wu, R.-Y. & Derynck, R. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168–172 ( 1996).
  Article ADS CAS Google Scholar
• Zhang, Y., Musci, T. & Derynck, R. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr. Biol. 7, 270– 276 (1997).
  Article Google Scholar
• de Groot, R. P. & Kruijer, W. Transcriptional activatin by TGF-β mediated by the DYAD symmetry element (DSE) and the TPA responsive element (TRE). Biochem. Biophys. Res. Commun. 168, 1074–1081 (1990).
  Article CAS Google Scholar
• Keeton, M. R., Curriden, S. A., van Zonneveld, A. & Loskutoff, D. J. Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor β. J. Biol. Chem. 266, 23048–23052 (1991).
  CAS PubMed Google Scholar
• Jin, G. & Howe, P. H. Regulation of clusterin gene expression by transforming growth factor β. J. Biol. Chem. 272, 26620–26626 (1997).
  Article CAS Google Scholar
• Felts, S. J., Stoflet, E. S., Eggers, C. T. & Getz, M. J. Tissue factor gene transcription in serum-stimualted fibroblasts is mediated by recruitment of c-Fos into specific AP-1 DNA-binding complexes. Biochemistry 34, 12355–12362 (1995).
  Article CAS Google Scholar
• Angel, P. & Karin, M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129–157 ( 1991).
  CAS PubMed Google Scholar
• Wrana, J. L. et al. TGF-β signals though a heteromeric protein kinase receptor complex. Cell 71, 1003– 1014 (1992).
  Article CAS Google Scholar
• Nakao, A. et al. TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO J. 16, 5353– 5362 (1997).
  Article CAS Google Scholar
• Renshaw, M. W., McWhirter, J. R. & Wang, J. Y. The human leukemia oncogene bcr-abl abrogates the anchorage requirement but not the growth factor requirement for proliferation. Mol. Cell. Biol. 15, 1286– 1293 (1995).
  Article CAS Google Scholar
• Angel, P. et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49, 729–739 (1987).
  Article CAS Google Scholar
• Wu, R.-Y., Zhang, Y., Feng, X.-H. & Derynck, R. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17, 2521–2528 (1997).
  Article CAS Google Scholar
• Chiu, R. et al. The c-Fos protein interacts wit c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54, 541– 552 (1988).
  Article CAS Google Scholar
• Yang-Yen, H. F., Chiu, R. & Karin, M. Elevationof AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription. New Biol. 2, 351– 361 (1990).
  CAS PubMed Google Scholar
• Feng, X.-H., Zhang, Wu, R.-Y. & Derynck, R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes Dev. 12, 2153–2163 (1998).
  Article CAS Google Scholar
• Hata, A., Lo, R. S., Wotton, D., Lagna, G. & Massagué, J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388, 82–87 (1997).
  Article ADS CAS Google Scholar
• Liu, F. et al. Ahuman Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 620–623 ( 1996).
  Article ADS CAS Google Scholar
• Feng, X.-H., Filvaroff, E. H. & Derynck, R. TGF-β-induced down-regulation of cyclin A expression requries a functional TGF-β receptor complex. Characterization of chimeric and truncated type I and type II receptors. J. Biol. Chem. 270, 24237–24245 (1995).
  Article CAS Google Scholar
• Yoshizumi, M. et al . Down-regulation of the cyclin A promoter by transforming growth factor-β1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J. Biol. Chem. 272, 22259– 22264 (1997).
  Article CAS Google Scholar
• Yingling, J. M. et al . Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol. 17, 7019–7028 (1997).
  Article CAS Google Scholar
• Zawel, L. et al. Human Smad3 and Smad4 are sequence-specific transcription activator. Mol. Cell 1, 611–176 (1998).
  Article CAS Google Scholar
• Karin, M. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270, 16483–16486 (1995).
  Article CAS Google Scholar
• Lloyd, A., Yancheva, N. & Wasylyk, B. Transformation suppressor activity of a Jun transcription factor lacking its activation domain. Nature 352, 635–638 (1991).
  Article ADS CAS Google Scholar
• Kretzschmar, M., Doody, J. & Massagué, J. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature 389, 618–622 (1997).
  Article ADS CAS Google Scholar
• de Caestecker, M. P. et al. Smad2 transduces common signals from serine-threonine and tyrosine kinases. Genes Dev. 1 2, 1587 –1592 (1998).
  Article Google Scholar
• Graycar, J. L. et al . Human transforming growth factor-β3: recombinant expression, purification, and biological activities in comparison with transforming growth factor-β1 and -β2. Mol. Endocrinol. 3, 1977–1986 (1989).
  Article CAS Google Scholar
• Sadowski, I. & Ptashne, M. Avector for expressing GAL4(1–147) fusions in mammalian cells. Nucleic Acids Res. 17, 7539 (1989).
  Article CAS Google Scholar
• Feng, X.-H. & Derynck, R. Ligand-independent activationof TGF-β signaling pathways by heteromeric cytoplasmic domains of TGF-β receptors. J. Biol. Chem. 271, 13123– 13129 (1996).
  Article CAS Google Scholar