A bifunctional gene product involved in two phases of the yeast cell cycle (original) (raw)
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- Published: 22 July 1982
Nature volume 298, pages 391–393 (1982)Cite this article
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Abstract
The cell cycle in Saccharomyces cerevisiae is divided into two distinct phases. Unbudded, mononucleate cells in the G1 phase can react to relevant environmental changes by mating1, sporulating2, or by entering stationary phase3. DNA synthesis and bud initiation occur almost simultaneously and mark ‘commitment’ to the completion of mitosis. Temperature-sensitive mutations at the cdc28 locus are known to cause arrest in the G1 phase of the cell cycle at the restrictive temperature4,5. Here we show that the cdc28 gene product is also active in post-G1 cell cycle functions, and that a different property of the gene product may be required for each phase of the cycle in which it acts.
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References
- Bucking-Throm, E., Duntze, W., Hartwell, L. H. & Manney, T. R. Expl Cell Res. 76, 99–110 (1973).
Article CAS Google Scholar - Hirschberg, J. & Simchen, G. Expl Cell Res. 105, 245–252 (1977).
Article CAS Google Scholar - Johnston, G. C., Pringle, J. R. & Hartwell, L. H. Expl Cell Res. 105, 79–98 (1977).
Article CAS Google Scholar - Hartwell, L. H., Mortimer, R. K., Culotti, J. & Culotti, M. Genetics 74, 267–286 (1973).
CAS PubMed PubMed Central Google Scholar - Reed, S. I. Genetics 95, 561–577 (1980).
CAS PubMed PubMed Central Google Scholar - Rai, R. & Carter, B. L. A. Molec. gen. Genet. 181, 556–558 (1981).
Article CAS PubMed Google Scholar - Hartwell, L. H., Culotti, J. & Reid, B. Proc. natn. Acad. Sci. U.S.A. 66, 352–359 (1970).
Article ADS CAS Google Scholar - Carter, B. L. A. The Cell Cycle (ed. John, P. C. L.) (Cambridge University Press, 1981).
Google Scholar - Hereford, L. M. & Hartwell, L. H. J. molec. Biol. 84, 445–461 (1974).
Article CAS PubMed Google Scholar - Byers, B. & Goetsch, L. Cold Spring Harb. Symp. quant. Biol. 38, 23–131 (1973).
Google Scholar - Byers, B. Molecular Genetics in Yeast. Alfred Benzon Symp. 16 (Munksgaard, Copenhagen, 1981).
- Hartwell, L. H. J. Bact. 115, 966–974 (1973).
CAS PubMed PubMed Central Google Scholar - Sloat, B. F. & Pringle, J. R. Science 200, 1171–1173 (1978).
Article ADS CAS PubMed Google Scholar - Robinow, C. F. & Marak, J. J. Cell Biol. 29, 129–151 (1966).
Article CAS PubMed PubMed Central Google Scholar - Pringle, J. R. & Hartwell, L. H. Molecular Biology of the Yeast Saccharomyces (eds Strathern, J. et al.). (Cold Spring Harbor Laboratory, New York, 1981).
Google Scholar - Fink, G. R. Genetics 53, 445–459 (1966).
CAS PubMed PubMed Central Google Scholar - Nurse, P. & Bissett, Y. Nature 292, 558–560 (1981).
Article ADS CAS PubMed Google Scholar - Williamson, D. H. & Fennell, D. J. Methods in Cell Biology (ed. Prescott, D. M.) 335–372 (Academic, 1975).
Google Scholar - Hartwell, L. H. J. Bact. 104, 1280–1285 (1975).
Google Scholar
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Authors and Affiliations
- Department of Genetics, University of Dublin, Trinity College, Dublin, 2, Ireland
J. R. Piggott, R. Rai & B. L. A. Carter
Authors
- J. R. Piggott
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Piggott, J., Rai, R. & Carter, B. A bifunctional gene product involved in two phases of the yeast cell cycle.Nature 298, 391–393 (1982). https://doi.org/10.1038/298391a0
- Received: 19 March 1982
- Accepted: 21 May 1982
- Issue Date: 22 July 1982
- DOI: https://doi.org/10.1038/298391a0