Immunoglobulin heavy chain binding protein (original) (raw)

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• Published: 24 November 1983

Nature volume 306, pages 387–389 (1983)Cite this article

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Abstract

Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain1. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.

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Authors and Affiliations

1. Friedrich-Miescher-Laboratorium, der Max-Planck-Gesellschaft, Spemannstrasse 37–39, D-7400, Tübingen, FRG
   Ingrid G. Haas & Matthias Wabl

Authors

1. Ingrid G. Haas
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2. Matthias Wabl
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Haas, I., Wabl, M. Immunoglobulin heavy chain binding protein.Nature 306, 387–389 (1983). https://doi.org/10.1038/306387a0

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• Received: 04 May 1983
• Accepted: 27 September 1983
• Issue Date: 24 November 1983
• DOI: https://doi.org/10.1038/306387a0