Regional specialization of retinal glial cell membrane (original) (raw)

Nature volume 309, pages 155–157 (1984)Cite this article

Abstract

Neural activity generates increases in extracellular K+ concentration, [K+]0, which must be regulated in order to maintain normal brain function1. Glial cells are thought to play an important part in this regulation through the process of K+ spatial buffering2–4: K+-mediated current flow through glial cells redistributes extracellular K+ following localized [K+]0 increases. As is the case in other glia, the retinal Müller cell is permeable almost exclusively to K+ (ref. 5). Recent experiments6–8 have suggested that this K+ conductance may not be distributed uniformly over the cell surface. In the present study, two novel techniques have been used to assess the Müller cell K+ conductance distribution. The results demonstrate that 94% of all membrane conductance lies in the endfoot process of the cell. This strikingly asymmetric distribution has important consequences for theories concerning K+ buffering and should help to explain the generation of the electroretinogram.

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Authors and Affiliations

  1. Eye Research Institute of Retina Foundation, 20 Staniford Street, Boston, Massachusetts, 02114, USA
    Eric A. Newman

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  1. Eric A. Newman
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Newman, E. Regional specialization of retinal glial cell membrane.Nature 309, 155–157 (1984). https://doi.org/10.1038/309155a0

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