A transposon-like element in human DNA (original) (raw)
- Letter
- Published: 25 July 1985
- Niren Deka1,
- Carl W. Schmid1,
- Ravi Misra2,
- Christian W. Schindler2,
- Mark G. Rush2,
- Lisa Kadyk3 &
- …
- Leslie Leinwand3
Nature volume 316, pages 359–361 (1985)Cite this article
- 315 Accesses
- 140 Citations
- 3 Altmetric
- Metrics details
Abstract
Mobile genetic elements have been reported in prokaryotes, plants, yeast and Drosophila (reviewed in refs 1, 2). The only transposonlike sequences reported for mammalian organisms are closely related to retroviruses3–7, although undoubtedly other transposon families exist within the mammalian genome. Although mobile genetic elements can only be identified as such if their mobility can be demonstrated in existing populations, transposon and transposon-like elements share several common biochemical and structural features1,2. Here we demonstrate that a repetitive human sequence has many of the diagnostic features of transposable elements. This 2.3-kilobase (kb) transposon-like element contains two flanking long terminal repeat (LTR)-like 350-base pair (bp) repetitive sequences, each of which begins with the sequence 5′ TG… and ends with …CA 3′. The transposon-like element is bounded by 5-bp direct repeats. Discrete-length polyadenylated transcripts from HeLa cells are homologous to the transposon-like element. Members of this transposon-like family are found in extrachromosomal circular DNA molecules.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Flavell, A. J. & Ish-Horowicz, D. Nature 292, 591–595 (1981).
Article ADS CAS Google Scholar - Temin, H. M. Cell 21, 599–600; 27, 1–3 (1980).
Article CAS Google Scholar - Varmus, H. E. Science 216, 812–820 (1982).
Article ADS CAS Google Scholar - Schmidt, M., Gloggler, K., Wirth, T. & Horak, I. Proc. natn. Acad. Sci. U.S.A. 81, 6696–6700 (1984).
Article ADS CAS Google Scholar - Streck, R. E. Nature 298, 767–769 (1982).
Article ADS Google Scholar - Kuff, E. L. et al. Proc. natn. Acad. Sci. U.S.A. 80, 1992–1996 (1983).
Article ADS CAS Google Scholar - Mager, D. L. & Henthorn, P. J. Proc. natn. Acad. Sci. U.S.A. 81, 7510–7514 (1984).
Article ADS CAS Google Scholar - Sun, L., Paulson, K. E., Schmid, C. W., Kadyk, L. & Leinwand, L. Nucleic Acids Res. 12, 2669–2690 (1984).
Article CAS Google Scholar - Elder, R. T., Loh, E. Y. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 80, 2432–2436 (1983).
Article ADS CAS Google Scholar - Flavell, A. J., Levis, R., Simon, M. A. & Rubin, G. M. Nucleic Acids Res. 9, 6279–6291 (1981).
Article CAS Google Scholar - Rose, A. M. & Snutch, T. P. Nature 311, 485–486 (1984).
Article ADS CAS Google Scholar - Krolewski, J. J. & Rush, M. G. J. molec. Biol 174, 31–40 (1984).
Article CAS Google Scholar - Schindler, C. W. & Rush, M. G. J. molec. Biol. (in the press).
- Schmid, C. W. & Jelinek, W. R. Science 216, 1065–1070 (1982).
Article ADS CAS Google Scholar - Singer, M. F., Thayer, R. E., Grimaldi, G., Leeman, M. I. & Fanning, T. G. Nucleic Acids Res. 11, 5739–5745 (1983).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Department of Chemistry, University of California, Davis, California, 95616, USA
K. Eric Paulson, Niren Deka & Carl W. Schmid - Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York City, New York, 10016, USA
Ravi Misra, Christian W. Schindler & Mark G. Rush - Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
Lisa Kadyk & Leslie Leinwand
Authors
- K. Eric Paulson
You can also search for this author inPubMed Google Scholar - Niren Deka
You can also search for this author inPubMed Google Scholar - Carl W. Schmid
You can also search for this author inPubMed Google Scholar - Ravi Misra
You can also search for this author inPubMed Google Scholar - Christian W. Schindler
You can also search for this author inPubMed Google Scholar - Mark G. Rush
You can also search for this author inPubMed Google Scholar - Lisa Kadyk
You can also search for this author inPubMed Google Scholar - Leslie Leinwand
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Paulson, K., Deka, N., Schmid, C. et al. A transposon-like element in human DNA.Nature 316, 359–361 (1985). https://doi.org/10.1038/316359a0
- Received: 11 March 1985
- Accepted: 22 May 1985
- Issue Date: 25 July 1985
- DOI: https://doi.org/10.1038/316359a0