Identity of cells that imprint H–2-restricted T-cell specificity in the thymus (original) (raw)

Nature volume 319, pages 672–675 (1986)Cite this article

Abstract

The thymus has two important roles in controlling the specificity of T lymphocytes. First, T cells differentiating in the thymus are rendered tolerant of ‘self’ antigens, particularly antigens encoded by the major histocompatibility complex, the H–2 complex in mice1. Second, the thymus imbues T cells with the property of H–2-restricted recognition of antigen, that is, the capacity of T cells to react with foreign antigens presented in association with self H–2 gene products2,3. Until recently it has generally been assumed that self-tolerance and H–2-restricted specificity both reflect early T-cell contact with self H–2 determinants expressed on thymic epithelial cells. Recent evidence suggests, however, that intrathymic cells of the macrophage/dendritic cell (MØ/DC) lineage also have a role in shaping T-cell specificity4–7. In particular, it has been found that the tolerance to graft-type H–2 determinants which normally ensues when T cells differentiate in an H–2-different thymus fails to occur when the thymus is pretreated with deoxyguanosine (dGuo)6,7,a procedure that selectively destroys MØ/DC but spares epithelial cells8. In contrast to these findings on tolerance induction, evidence is presented here that dGuo-treated thymus grafts do imprint T cells with H–2-restricted specificity for antigen. It appears, therefore, that induction of tolerance and H–2 restriction are controlled by different cells in the thymus.

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  1. Department of Immunology, IMM4, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA
    David Lo & Jonathan Sprent

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  1. David Lo
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  2. Jonathan Sprent
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Lo, D., Sprent, J. Identity of cells that imprint H–2-restricted T-cell specificity in the thymus.Nature 319, 672–675 (1986). https://doi.org/10.1038/319672a0

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