Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin (original) (raw)

• Letter
• Published: 06 November 1986
• Kiyoshi Yasukawa1,
• Hisashi Harada1 na1,
• Tetsuya Taga1,
• Yasuo Watanabe1,
• Tadashi Matsuda1,
• Shin-ichiro Kashiwamura1,
• Koichi Nakajima1,
• Koichi Koyama1,
• Akihiro Iwamatsu1 na2,
• Susumu Tsunasawa1 na2,
• Fumio Sakiyama1 na2,
• Hiroshi Matsui1 na3,
• Yoshiyuki Takahara1 na3,
• Tadatsugu Taniguchi1 na1 &
• …
• Tadamitsu Kishimoto1

Nature volume 324, pages 73–76 (1986)Cite this article

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Abstract

When stimulated with antigen, B cells are influenced by T cells to proliferate and differentiate into antibody-forming cells. Since it was reported1,2 that soluble factors could replace certain functions of helper T cells in the antibody response, several different kinds of lymphokines and monokines have been reported in B-cell growth and differentiation3,4. Among these, human B-cell differentiation factor (BCDF or BSF-2) has been shown to induce the final maturation of B cells into immunoglobulin-secreting cells5–8. BSF-2 was purified to homogeneity9 and its partial NH2-terminal amino-acid sequence was determined10. These studies indicated that BSF-2 is functionally and structurally unlike other known proteins. Here, we report the molecular cloning, structural analysis and functional expression of the cDNA encoding human BSF-2. The primary sequence of BSF-2 deduced from the cDNA reveals that BSF-2 is a novel interleukin consisting of 184 amino acids.

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Author notes

1. Hisashi Harada and Tadatsugu Taniguchi: Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, 1–3, Yamada-Oka, Suita, Osaka 565, Japan
2. Akihiro Iwamatsu, Susumu Tsunasawa and Fumio Sakiyama: Division of Protein Chemistry, Institute for Protein Research, Osaka University, 1–3, Yamada-Oka, Suita, Osaka 565, Japan
3. Hiroshi Matsui and Yoshiyuki Takahara: Central Research Laboratories, Ajinomoto Co. Inc., Totsuka-ku, Yokohama 244, Japan

Authors and Affiliations

1. Division of Immunology, Osaka University, 1–3, Yamada-Oka, Suita, Osaka, 565, Japan
   Toshio Hirano, Kiyoshi Yasukawa, Hisashi Harada, Tetsuya Taga, Yasuo Watanabe, Tadashi Matsuda, Shin-ichiro Kashiwamura, Koichi Nakajima, Koichi Koyama, Akihiro Iwamatsu, Susumu Tsunasawa, Fumio Sakiyama, Hiroshi Matsui, Yoshiyuki Takahara, Tadatsugu Taniguchi & Tadamitsu Kishimoto

Authors

1. Toshio Hirano
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2. Kiyoshi Yasukawa
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3. Hisashi Harada
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4. Tetsuya Taga
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5. Yasuo Watanabe
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6. Tadashi Matsuda
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7. Shin-ichiro Kashiwamura
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8. Koichi Nakajima
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9. Koichi Koyama
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10. Akihiro Iwamatsu
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11. Susumu Tsunasawa
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12. Fumio Sakiyama
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13. Hiroshi Matsui
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14. Yoshiyuki Takahara
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15. Tadatsugu Taniguchi
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16. Tadamitsu Kishimoto
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Hirano, T., Yasukawa, K., Harada, H. et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.Nature 324, 73–76 (1986). https://doi.org/10.1038/324073a0

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• Received: 04 August 1986
• Accepted: 26 September 1986
• Issue Date: 06 November 1986
• DOI: https://doi.org/10.1038/324073a0

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