The transcription factor NF-ATc is essential for cardiac valve formation (original) (raw)

• McCaffrey, P. G. et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262, 750–754 (1993).
  Article ADS CAS Google Scholar
• Rao, A., Luo, C. & Hogan, P. G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707–747 (1997).
  Article CAS Google Scholar
• Hoey, T., Sun, Y.-L., Williamson, K. & Xu, X. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2, 461–472 (1995).
  Article CAS Google Scholar
• Northrop, J. P. et al. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497–502 (1994).
  Article ADS CAS Google Scholar
• Emmel, E. A. et al. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246, 1617–1620 (1989).
  Article ADS CAS Google Scholar
• Timmerman, L. A., Clipstone, N. A., Ho, S. N., Northrop, J. P. & Crabtree, G. R. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 383, 837–840 (1996).
  Article ADS CAS Google Scholar
• Rossant, J. Mouse mutants and cardiac development. Circ. Res. 78, 349–353 (1996).
  Article CAS Google Scholar
• Eisenburg, L. M. & Markwald, R. R. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77, 106 ((1995)).
  Google Scholar
• Kwee, L. et al. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489–503 (1995).
  CAS PubMed Google Scholar
• Baldwin, H. S., Jensen, K. L. & Solursh, M. Myogenic cytodifferentiation of the precardiac mesoderm in the rat. Differentiation 47, 163–172 (1991).
  Article CAS Google Scholar
• Copp, A. J. Death before birth: clues from gene knockouts and mutations. Trends Genet. 11, 87–93 (1995).
  Article CAS Google Scholar
• Olson, E. N. & Srivastava, D. Molecular pathways controlling heart development. Science 272, 671–676 (1966).
  Article ADS Google Scholar
• Fishman, M. C. & Chien, K. R. Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099–2177 (1997).
  CAS PubMed Google Scholar
• Ferencz, C. et al. Congenital heart disease: prevalence at live birth. Am. J. Epidemiol. 121, 31–36 (1985).
  Article CAS Google Scholar
• Kwee, L. et al. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489–503 (1995).
  CAS PubMed Google Scholar
• Moens, C. B., Stanton, B. R., Parada, L. F. & Rossant, J. Defects in heart and lung development in compound heterozygotes for two different targeted mutations of the N-myc locus. Development 119, 485–499 (1993).
  CAS PubMed Google Scholar
• Meyer, D. & Birchmeier, C. Multiple essential functions of neuregulin in development. Nature 23, 386–390 (1995).
  Article ADS Google Scholar
• Gassmann, M. et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390–394 (1995).
  Article ADS CAS Google Scholar
• Lee, K. F. et al. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394–398 (1995).
  Article ADS CAS Google Scholar
• Yang, J. T., Rayburn, H. & Hynes, R. O. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development 121, 549–560 (1995).
  CAS PubMed Google Scholar
• Schilham, M. W. et al. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature 380, 711–714 (1996).
  Article ADS CAS Google Scholar
• Miyabara, S. et al. Absent aortic and pulmonary valves: investigation of three fetal cases with cystic hygroma and review of the literature. Heart Vessels 9, 49–55 (1994).
  Article CAS Google Scholar
• Brown, P. A. J., Gray, E. S., Whiting, P. H., Simpson, J. G. & Thomson, A. W. Effects of cyclosporin A on fetal development in the rat. Biol. Neonate 48, 172–180 (1985).
  Article CAS Google Scholar
• Lyons, K. M., Hogan, B. L. & Robertson, E. J. Colocalization of BMP-7 and BMP2 RNAs suggest that these factors cooperatively mediate tissue interactions during murine development. Mech. Dev. 50, 71–83 (1995).
  Article CAS Google Scholar
• Yamamura, H., Zhang, M., Markwald, R. R. & Mjaatvedt, C. H. Aheart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Dev. Biol. 186, 58–72 (1997).
  Article CAS Google Scholar
• Clark, E. B. in Genetics of Cardiovascular Disease (eds Pierpont, M. E. & Moller, J. H.) 3–11 (Martinus-Nijhoff, Boston, Massachusetts, (1987)).
  Book Google Scholar
• Tian, H., McKnight, S. L. & Russell, D. W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72–82 (1997).
  Article CAS Google Scholar
• Hurle, J. M., Colveé, E. & Blanco, A. M. Development of mouse semilunar valves. Anat. Embryol. 160, 83–91 (1980).
  Article CAS Google Scholar
• Markwald, R. R. et al. in The Role of Extracellular Matrix in Development (ed. Trelstead, R. L.) 323–350 (Allan R, Liss Inc, New York, (1994)).
  Google Scholar
• Runyan, R. B. et al. Signal transduction of a tissue interaction during embryonic heart development. Cell Regulation 1, 301–313 (1990).
  Article CAS Google Scholar
• Sturm, K. & Tam, P. P. L. Methods Enzymol. 225, 164–190 (1993).
  Google Scholar