Altered DNA ligase I activity in Bloom's syndrome cells (original) (raw)
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- Published: 22 January 1987
Nature volume 325, pages 357–359 (1987)Cite this article
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Abstract
Cells from patients with Bloom's syndrome, a rare disease associated with increased cancer frequency, exhibit cytological abnormalities1–3. These include increased numbers of homologous chromatid interchange figures and sister-chromatid exchanges, together with abnormally slow replicon-fork progression4–6 and retarded rate of DNA-chain maturation7,8, and suggest that the primary defect in this recessive disorder affects S-phase DNA replication. DNA ligases and DNA polymerases have long been prime candidates for abnormality in Bloom's syndrome, but various studies of DNA polymerases in Bloom's syndrome cells have disclosed no abnormalities9–11. Evidence is presented here, as in the accompanying paper from a different laboratory12, for the existence in Bloom's syndrome of an abnormality of the DNA ligase involved in semi-conservative DNA replication.
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References
- German, J. Science 144, 298–301 (1964).
Article ADS CAS Google Scholar - German, J., Archibald, R. & Bloom, D. Science 148, 506–507 (1965).
Article ADS CAS Google Scholar - Chaganti, R. S. K., Schonberg, S. & German, J. Proc. natn. Acad. Sci. U.S.A. 71, 4508–4512 (1974).
Article ADS CAS Google Scholar - Hand, R. & German, J. Proc. natn. Acad. Sci U.S.A. 72, 758–762 (1975).
Article ADS CAS Google Scholar - Hand, R. & German, J. Hum. Genet. 38, 297–306 (1977).
Article CAS Google Scholar - Ockey, C. H. J. Cell Sci. 40, 125–144 (1979).
CAS PubMed Google Scholar - Giannelli, F., Benson, F., Pawsey, S. A. & Polani, P. D. Nature 265, 466–469 (1977).
Article ADS CAS Google Scholar - Kapp, L. N. Biochim. biophys. Acta 696, 226–227 (1982).
Article CAS Google Scholar - Parker, V. P. & Lieberman, M. W. Nucleic Acids Res. 4, 2029–2037 (1977).
Article CAS Google Scholar - Bertazzoni, U. et al. Nucleic Acids Res. 5, 2189–2196 (1978).
Article CAS Google Scholar - Spanos, A., Holliday, R. & German, J. Hum. Genet. 73, 119–122 (1986).
Article CAS Google Scholar - Willis, A. E. & Lindahl, T. Nature 325, 355–357 (1987).
Article ADS CAS Google Scholar - Soderall, S. & Lindahl, T. FEBS Lett. 67, 1–7 (1976).
Article Google Scholar - Teraoka, H., Shimoyachi, M. & Tsukada, K. FEBS Lett. 54, 217–220 (1975).
Article CAS Google Scholar - Pedrali-Noy, G. C. F., Spadari, S., Ciarrocchi, G., Pedrini, A. M. & Falaschi, A. Eur. J. Biochem. 39, 343–351 (1973).
Article CAS Google Scholar - Teraoka, H., Sumikawa, T. & Tsukada, K. J. biol. Chem. 261, 6886–6892 (1986).
Google Scholar - Arrand, J. E., Willis, A. T., Goldsmith, I. & Lindahl, T. J. biol Chem. 261, 9079–9082 (1986).
CAS PubMed Google Scholar - Mezzina, M. et al. Biochem. biophys. Res. Commun. 132, 857–863 (1985).
Article CAS Google Scholar - Mezzina, M., Sarasin, A., Polite, N. & Bertazzoni, U. Nucleic Acids Res. 12, 5109–5122 (1984).
Article CAS Google Scholar - Chan, J. Y. H. & Becker, F. F. Carcinogenesis 6, 1275–1277 (1985).
Article CAS Google Scholar - Ray, J. H. & German, J. Chromosoma 90, 383–388 (1984).
Article CAS Google Scholar - Henderson, E., Miller, G., Robinson, J. & Heston, L. Virology 76, 152–163 (1977).
Article CAS Google Scholar - Chan, J. Y. H., Thompson, L. H. & Becker, F. F. Mutat. Res. 131, 209–214 (1984).
CAS PubMed Google Scholar - Andrews, P. Biochem. J. 96, 595–606 (1965).
Article CAS Google Scholar - Modrich, P. & Lehman, A. R. J. biol Chem. 245, 3626–3631 (1970).
CAS PubMed Google Scholar - Chan, J. Y. H. & Becker, F. F. Biochem. J. 193, 985–990 (1981).
Article CAS Google Scholar
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Authors and Affiliations
- Experimental Pathology, University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas, 77030, USA
John Y. H. Chan & Frederick F. Becker - The New York Blood Center, New York, New York, 10021, USA
James German & James H. Ray
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- John Y. H. Chan
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Chan, J., Becker, F., German, J. et al. Altered DNA ligase I activity in Bloom's syndrome cells.Nature 325, 357–359 (1987). https://doi.org/10.1038/325357a0
- Received: 08 October 1986
- Accepted: 10 November 1986
- Issue Date: 22 January 1987
- DOI: https://doi.org/10.1038/325357a0