Different rhinovirus serotypes neutralized by antipeptide antibodies (original) (raw)

Nature volume 329, pages 736–738 (1987)Cite this article

Abstract

Recently, Rossman et al.1 have described the three-dimensional structure of a human rhinovirus. A possible host cell surface receptor binding site was identified with a cleft on each icosahedral face. Two highly conserved amino-acid sequences found in rhino-, polio-, and foot-and-mouth disease (FMD) viruses are located near the base of this site and could be important in maintaining its topology. We have prepared site-specific antibodies2,3 to two synthetic peptides which include these sequences. The antibodies bind to the predicted capsid proteins of rhinovirus and neutralize ˜60% of 48 rhinovirus serotypes tested. These results could provide a route to a rhinovirus vaccine effective against most of the numerous serotypes of this virus.

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References

  1. Rossmann, M. G. et al. Nature 317, 145–153 (1985).
    Article ADS CAS Google Scholar
  2. Lerner, R. A. Adv. Immun. 36, 1–44 (1984).
    Article CAS Google Scholar
  3. Shinnick, T. M., Sutcliffe, J. G., Green, N. & Lerner, R. A. A. Rev. Microbiol. 37, 425–446 (1983).
    Article CAS Google Scholar
  4. Hirayama, A., Takagaki, Y. & Karush, F. J. Immun. 134, 3241–3247 (1985).
    CAS PubMed Google Scholar
  5. Mueller, G. M., Shapira, M. & Arnon, R. Proc. natn. Acad. Sci. U.S.A. 79, 569–573 (1982).
    Article ADS CAS Google Scholar
  6. Emini, E. A., Hughes, J. V., Perlow, D. S. & Boger, J., J. Virol. 55, 836–839 (1985).
    CAS PubMed PubMed Central Google Scholar
  7. Cohen, G. H. et al. J. Virol. 49, 102–108 (1984).
    CAS PubMed PubMed Central Google Scholar
  8. Emini, E. A., Jameson, B. A. & Wimmer, E. J. Virol. 52, 719–721 (1984).
    CAS PubMed PubMed Central Google Scholar
  9. Chow, M., Yabrov, R., Bittte, J., Hogle, J. & Baltimore, D. Proc. natn. Acad. Sci. U.S.A. 82, 910–914 (1985).
    Article ADS CAS Google Scholar
  10. Colonno, R. J., Callahan, P. L. & Long, W. J. J. Virol. 57, 7–12 (1986).
    CAS PubMed PubMed Central Google Scholar
  11. Skern, T. et al. Nucleic Acids Res. 13, 2111–2126 (1985).
    Article CAS Google Scholar
  12. Dimmock, N. J., Trends biochem. Sci. 12, 70–75 (1987).
    Article CAS Google Scholar
  13. Luo, M. et al. Science 235, 182–191 (1987).
    Article ADS CAS Google Scholar
  14. Chedid, L. et al. Biochem. biophys. Res. Commun. 117, 908–915 (1983).
    Article CAS Google Scholar
  15. Werner, G. et al. J. Virol 57, 1084–1093 (1986).
    CAS PubMed PubMed Central Google Scholar
  16. Towbin, H., Staehelin, T. & Gordon, J. Proc. natn. Acad. Sci. U.S.A. 76, 4350–4354 (1979).
    Article ADS CAS Google Scholar
  17. Green, N. et al. Cell 28, 477–487 (1982).
    Article CAS Google Scholar

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  1. Sandoz Forschungsinstitut, Brunner Strasse 59, A-1235, Vienna, Austria
    Joseph McCray & Gudrun Werner

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  1. Joseph McCray
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  2. Gudrun Werner
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McCray, J., Werner, G. Different rhinovirus serotypes neutralized by antipeptide antibodies.Nature 329, 736–738 (1987). https://doi.org/10.1038/329736a0

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