Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve (original) (raw)

Nature volume 330, pages 658–659 (1987)Cite this article

Abstract

The Schwann cells and fibroblast-like cells of the intact sciatic nerve of adult rats synthesize very little nerve growth factor (NGF) (ref. 1). After lesion, however, there is a dramatic increase in the amounts of both NGF-mRNA and NGF protein synthesized by the sciatic non-neuronal cells1,2. This local increase in NGF synthesis partially replaces the interrupted NGF supply from the periphery to the NGF-responsive sensory and sympathetic neurons, whose axons run within the sciatic nerve1. Macrophages, known to invade the site of nerve lesion during wallerian degeneration3,4, are important in the regulation of NGF synthesis5. Here we demonstrate that the effect of macrophages on NGF-mRNA levels in cultured explants of sciatic nerve can be mimicked by conditioned media of activated macrophages, and that interleukin-1 is the responsible agent.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. 1. Heumann, R., Korsching, S., Bandtlow, C. & Thoenen, H. J. cellBiol 104,1623-1631 (1987). 2. Bandtlow, C. E., Heumann, R., Schwab, M. E. & Thoenen, H. EMBOJ. 6, 891-899 (1987). 3. Perry, V. H., Brown, M. C. & Gordon, S. /. exp. Med. 165, 1218-1223 (1987). 4. Stoll, G. & Miiller, H. W. Neurosci. Lett. 72, 233-238 (1986). 5. Heumann, R. J. exp. Biol. 132, 133-150 (1987). 6. Nathan, C. F., Murray, H. W. & Cohn, Z A. New Engl. J. Med. 303, 622-626 (1980). 7. Shimokado, K. et al. Cell 43, 277-286 (1985). 8. Wingfield, P. et al. Eur. J. Biochem. 160, 491-497 (1986). 9. Oppenheim, J. J., Kovacs, E. J., Matsushima, K. & Durum, S. K. Immun. Today 7, 45-56 (1986). 10. March, C. J. et al Nature 315, 641-647 (1985). 11. Lomedico, P. T. et al. Nature 312, 458-461 (1984). 12. Auron, P. E. et al. Proc. natn. Acad. Sci. U.S.A. 81, 7907-7911 (1984). 13. Giulian, D., Baker, T. J., Shih, L.-C. N. & Lachman, L. B. /. exp. Med. 164, 594-604 (1986). 14. Giulian, D. & Lachman, L. B. Science 228, 497-499 (1985). 15. Fontana, A., Kristensen, F., Dubs, R., Gemsa, D. & Weber, E. J. Immun. 129, 2413-2419 (1982). 16. Heumann, R. & Thoenen, H. /. biol. Chem. 261, 9246-9249 (1986). 17. Dijkstra, C. D., Dopp, E. A., Joling, P. & Kraal, G. Immunology 54, 589-599 (1985). 18. Brandwein, S. R. J. biol. Chem. 261, 8624-8632 (1986). 19. Pettman, B., Labourdette, G., Weibel, M. & Sensenbrenner, M. Neurosci. Lett. 68,175-180 (1986). 20. Grennberg, M. E. & Ziff, E. B. Nature 311, 433-438 (1984). 21. Bevilacqua, M. P. et al. Proc. natn. Acad. Sci. U.S.A. 83, 4533-4537 (1986).

Download references

Author information

Authors and Affiliations

  1. Department of Neurochemistry, Max-Planck-Institute for Psychiatry, D-8033, Planegg-Martinsried, FRG
    Dan Lindholm, Rolf Heumann, Michael Meyer & Hans Thoenen

Authors

  1. Dan Lindholm
    You can also search for this author inPubMed Google Scholar
  2. Rolf Heumann
    You can also search for this author inPubMed Google Scholar
  3. Michael Meyer
    You can also search for this author inPubMed Google Scholar
  4. Hans Thoenen
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Lindholm, D., Heumann, R., Meyer, M. et al. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve .Nature 330, 658–659 (1987). https://doi.org/10.1038/330658a0

Download citation

This article is cited by