Soluble CD4 molecules neutralize human immunodeficiency virus type 1 (original) (raw)

Nature volume 331, pages 84–86 (1988)Cite this article

Abstract

Human immunodeficiency virus (HIV) infection can bring about total collapse of the immune system1,2 by infecting helper T lymphocytes which express CD4, the molecule which mediates interaction between the cell surface and viral envelope glycoprotein gp!20 (refs 3–10). HIV apparently escapes the effects of neutralizing antibodies in vivo by generating new variants which must still interact with CD4 to maintain a cycle of infection11–14. One route to block HIV infection, therefore, could use solubilized CD4 protein to inhibit attachment of the virus to its target cell. We have used recombinant DNA techniques to generate soluble forms of CD4, and show here that these are potent inhibitors of HIV infection in vitro

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Author notes

  1. Wolfgang Lüke: Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Kellnerweg 4, Gottingen 3400, FRG

Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4058, Basel, Switzerland
    André Traunecker, Wolfgang Lüke & Klaus Karjalainen

Authors

  1. André Traunecker
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  2. Wolfgang Lüke
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  3. Klaus Karjalainen
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Traunecker, A., Lüke, W. & Karjalainen, K. Soluble CD4 molecules neutralize human immunodeficiency virus type 1.Nature 331, 84–86 (1988). https://doi.org/10.1038/331084a0

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