Essential role of mouse telomerase in highly proliferative organs (original) (raw)

• Greider, C. W. Telomere length regulation. Annu. Rev. Biochem. 65, 337–365 (1996).
  Article CAS PubMed Google Scholar
• Muller, H. J. The remaking of chromosomes. Collect. Net 8, 182–195 (1938).
  Google Scholar
• McClintock, B. The stability of broken ends of chromosomes in Zea mays. Genetics 26, 234–282 ( 1941).
  CAS PubMed PubMed Central Google Scholar
• Greider, C. W. Chromosome first aid. Cell 67, 645– 647 (1991).
  Article CAS PubMed Google Scholar
• Greider, C. W. & Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405–413 ( 1985).
  Article CAS PubMed Google Scholar
• Greider, C. W. & Blackburn, E. H. Atelomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337, 331–337 (1989).
  Article ADS CAS PubMed Google Scholar
• Feng, J.et al. The RNA component of human telomerase. Science 269, 1236–1241 (1995).
  Article ADS CAS PubMed Google Scholar
• Lingner, J.et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561–567 (1997).
  Article CAS PubMed Google Scholar
• Harrington, L.et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 11, 3109–3115 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Kilian, A.et al. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns on different cell types. Hum. Mol. Genet. 6, 2011–2019 (1997).
  Article CAS PubMed Google Scholar
• Nakayama, J.et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nature Genet. 18, 65–68 (1998).
  Article CAS PubMed Google Scholar
• Meyerson, M.et al. HEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90, 785–795 ( 1997).
  Article CAS PubMed Google Scholar
• Nakamura, T. M.et al . Telomerase catalytic subunit homologs from fission yeast and human. Science 277, 955– 959 (1997).
  Article CAS PubMed Google Scholar
• Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during aging of human fibroblasts. Nature 345, 458–460 (1990).
  Article ADS CAS PubMed Google Scholar
• Hastie, N. D.et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866–868 (1990).
  Article ADS CAS PubMed Google Scholar
• Bodnar, A. G.et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349– 352 (1998).
  Article ADS CAS PubMed Google Scholar
• Counter, C. M.et al . Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921–1929 ( 1992).
  Article CAS PubMed PubMed Central Google Scholar
• Prowse, K. R. & Greider, C. W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl Acad. Sci. USA 92, 4818–4822 (1995).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Kim, N. W.et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011– 2015 (1994).
  Article ADS CAS PubMed Google Scholar
• Blasco, M. A.et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25– 34 (1997).
  Article CAS PubMed Google Scholar
• Singer, M. S. & Gottschling, D. E. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266, 403–409 (1994).
  Article ADS Google Scholar
• McEachern, M. J. & Blackburn, E. H. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376, 403–409 (1995).
  Article ADS CAS PubMed Google Scholar
• Haber, J. E. & Thorburn, P. C. Healing of broken linear dicentric chromosomes in yeast. Genetics 106, 207– 226 (1984).
  CAS PubMed PubMed Central Google Scholar
• Sandell, L. L. & Zakian, V. A. Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell 75, 729–739 (1993).
  Article CAS PubMed Google Scholar
• Wright, S. Systems of mating. Genetics 6, 111– 178 (1921).
  CAS PubMed PubMed Central Google Scholar
• Drost, J. B. & Lee, W. R. Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among Drosophila, mouse, and human. Environ. Mol. Mutagen. 25 (suppl. 26), 48–64 (1995).
  Article Google Scholar
• Shima, H., Motomu, T., Young, P. & Cunha, G. R. Postnatal growth of mouse seminal vesicle is dependent on 5α-dihydrotestosterone. Endocrinology 127, 3222–3233 (1990).
  Article CAS PubMed Google Scholar
• Erslev, A. J. & Lichtman, M. A. in Hematology 4th edn 37–47 (McGraw-Hill, (1993).
  Google Scholar
• Buchkovich, K. J. & Greider, C. W. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol. Biol. Cell 7, 1443–1454 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Weng, N.-P., Levine, B. L., June, C. H. & Hodes, R. J. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183, 2471– 2479 (1996).
  Article CAS PubMed Google Scholar
• Bodnar, A.. G., Kim, N. W., Effros, R. B. & Chiu, C. P. Mechanism of telomerase induction during T cell activation. Exp. Cell Res. 228, 58–64 ( 1996).
  Article CAS PubMed Google Scholar
• Garagna, S.et al. Robertsonian metacentrics of the house mouse lose telomeric sequences but retain some minor satellite DNA in the pericentromeric area. Chromosoma 103, 685–692 (1995).
  Article CAS PubMed Google Scholar
• Nanda, I., Schneider-Rasp, S., Winking, H. & Schmid, M. Loss of telomeric sites in the chromosomes of Mus musculus domesticus (Rodentia: Muridae) during Robertsonian rearrangement. Chromosome Res. 3, 399–409 ( 1995).
  Article CAS PubMed Google Scholar
• Zijlmans, J. M.et al . Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3repeats. Proc. Natl Acad. Sci. USA 94, 7423–7428 (1997).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Saltman, D., Morgan, R., Cleary, M. L. & de Lange, T. Telomeric structure in cells with chromosome end associations. Chromosoma 102, 121 (1993).
  Article CAS PubMed Google Scholar
• McEachern, M. J. & Blackburn, E. H. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CAPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10, 1822–1834 ( 1996).
  Article CAS PubMed Google Scholar
• Kipling, D. & Cooke, H. J. Hypervariable ultra-long telomeres in mice. Nature 347, 400– 402 (1990).
  Article ADS CAS PubMed Google Scholar
• Watt, S. M. & Visser, J. W. M. Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells. Cell Prolif. 25, 263–297 (1992).
  Article CAS PubMed Google Scholar
• Vindelov, L. L., Christensen, I. J. & Nissen, N. L. Adetergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3, 323–327 (1983).
  Article CAS PubMed Google Scholar
• Morgenbesser, S. D. et al. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371, 72–74 (1994).
  Article ADS CAS PubMed Google Scholar
• Cannizzaro, L. A. & Shi, G. Fluorescent in situ hybridization (FISH) for DNA probes in the interphase and metaphase stages of the cell cycle. Methods Mol. Biol. 75, 313–322 (1997).
  CAS PubMed Google Scholar