Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions (original) (raw)

References

  1. Plopper, G., McNamee, H. P., Dike, L. E., Bojanowski, K. & Ingber, D. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol. Biol. Cell. 6, 1349–1365 (1995).
    Article CAS Google Scholar
  2. Miyamoto, S. et al. Integrin function: molecular hierarchies of CSK and signaling molecules. J. Cell Biol. 131, 791–805 (1995).
    Article CAS Google Scholar
  3. Wang, N. J., Butler, P. & Ingber, D. E. Mechanotransduction across the cell surface and through the CSK. Science 260, 1124–1127 (1993).
    Article ADS CAS Google Scholar
  4. Benecke, B.-J., Ben-Ze'ev, A., Benecke, B.-J. & Penman, S. The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts. Cell 14, 931–939 (1978).
    Article CAS Google Scholar
  5. Farmer, S. R., Ben-Ze'ev, A. & Penman, S. Altered translatability of messenger RNA from suspended anchorage-dependent fibroblasts: reversal upon cell attachment to a surface. Cell 15, 627–637 (1978).
    Article CAS Google Scholar
  6. Bassell, G. & Singer, R. H. mRNA and cytoskeletal filaments. Curr. Opin. Cell Biol. 9, 109–115 (1997).
    Article CAS Google Scholar
  7. Plopper, G. & Ingber, D. E. Rapid induction and isolation of focal adhesion complexes. Biochem. Biophys. Res. Commun. 193, 571–578 (1993).
    Article CAS Google Scholar
  8. Latham, V., Kislauskis, E., Singer, R. & Ross, A. β-Actin mRNA localization is regulated by signal transduction mechanisms. J. Cell Biol. 126, 1211–1219 (1994).
    Article CAS Google Scholar
  9. Taneja, K. L., Lifshitz, L. M., Fay, F. S. & Singer, R. H. Poly(A) RNA codistribution with microfilaments: Evaluation by in situ hybridization and quantitative digital imaging microscopy. J. Cell Biol. 119, 1245–1260 (1992).
    Article CAS Google Scholar
  10. Bassell, G. J., Powers, C. M., Taneja, K. L. & Singer, R. H. Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections in fibroblasts. J. Cell Biol. 126, 863–876 (1994).
    Article CAS Google Scholar
  11. Ingber, D. E. Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton. J.Cell Sci. 104, 613–627 (1993).
    PubMed Google Scholar
  12. Wang, N. & Ingber, D. E. Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry. Biochem. Cell Biol. 73, 327–335 (1995).
    Article CAS Google Scholar
  13. Cramer, L. P. & Mitchison, T. J. Myosin is involved in postmitotic cell spreading. J. Cell Biol. 131, 179–189 (1995).
    Article CAS Google Scholar
  14. Nakanishi, S., Yamada, K., Iwahashi, K., Kuroda, K. & Kase, H. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmacol. 37, 482–488 (1990).
    CAS PubMed Google Scholar
  15. Long, R. M. et al. Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA. Science 277, 383–387 (1997).
    Article CAS Google Scholar
  16. Chrzanowska-Wodnicka, M. & Burridge, K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403–1415 (1996).
    Article CAS Google Scholar
  17. Ingber, D. E. et al. Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J. Cell Biol. 110, 1803–1811 (1990).
    Article CAS Google Scholar
  18. Edmonds, B. T., Murray, J. & Condeelis, J. pH regulation of the F-actin binding properties of Dictyostelium elongation factor 1a. J. Biol. Chem. 270, 15222–15230 (1995).
    Article CAS Google Scholar
  19. Vuori, K. & Ruoslahti, E. Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on FN. J. Biol. Chem. 268, 21459–21462 (1993).
    CAS PubMed Google Scholar
  20. Morley, S. J. Signal transduction mechanisms in the regulation of protein synthesis. Mol. Biol. Rep. 19, 221–231 (1994).
    Article CAS Google Scholar
  21. Whalen, S. G. et al. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. J. Biol. Chem. 271, 11831–11837 (1996).
    Article CAS Google Scholar
  22. Von Manteuffel, S., Gingras, A. C., Ming, X. F., Sonenberg, N. & Thomas, G. 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc. Natl Acad. Sci. USA 93, 4076–4080 (1996).
    Article ADS CAS Google Scholar
  23. Sonenberg, N. Regulation of translation and cell growth by eIF-4E. Biochimie 76, 839–846 (1994).
    Article CAS Google Scholar
  24. Singh, N. K., Attreya, C. D. & Nakhasi, H. L. Identification of calreticulin as a rubella virus RNA binding protein. Proc. Natl Acad. Sci. USA 91, 12770–12774 (1994).
    Article ADS CAS Google Scholar
  25. Schmeichel, K. L. & Beckerle, M. C. Molecular dissection of a LIM domain. Mol. Biol. Cell. 8, 219–230 (1997).
    Article CAS Google Scholar
  26. Wada, H., Ivester, C. T., Carabello, B. A., Cooper, G. & McDermott, P. J. Translational initiation factor eIF-4E. A link between cardiac load and protein synthesis. J. Biol. Chem. 271, 8359–8364 (1996).
    Article CAS Google Scholar
  27. Kourembanas, S., Hannan, R. L. & Faller, D. V. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain in human endothelial cells. J. Clin. Invest. 86, 670–674 (1990).
    Article CAS Google Scholar
  28. Lucas, J. J., Szekely, E. & Kates, J. R. The regeneration and division of mouse L-cell karyoplasts. Cell 7, 115–122 (1976).
    Article CAS Google Scholar
  29. Schwartz, M. A., Lechene, C. & Ingber, D. E. Insoluble FN activates the Na+/H+ antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proc. Natl Acad. Sci. USA 88, 7849–7853 (1991).
    Article ADS CAS Google Scholar
  30. Zhang, G., Taneja, K. L., Singer, R. H. & Green, M. R. Localization of pre-mRNA splicing in mammalian nuclei. Nature 372, 809–812 (1994).
    Article ADS CAS Google Scholar

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