Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques (original) (raw)
- Letter
- Published: 19 January 1989
- Keith A. Reimann1,
- Peter A. DeLong1,
- Theresa Liu1 na1,
- Richard A. Fisher1 na1 &
- …
- Norman L. Letvin1 na2
Nature volume 337, pages 267–270 (1989)Cite this article
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Abstract
The CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV-1)1 and a soluble truncated form of CD4 produced by recombinant DNA technology is a potent inhibitor of HIV-1 replication and HIV-1-induced cell fusion _in vitro_2–6. Rhesus monkeys infected with the simian immunodeficiency virus of macaques (SIVMAC), a virus closely related to HIV-1, develop an AIDS-like syndrome, and so provide an important model for the evaluation of potential AIDS therapies7. We have assessed the therapeutic effect of recombinant soluble CD4 in SIVMAC-infected rhesus monkeys. Virus was readily isolated from peripheral blood lymphocytes and bone marrow cells of these animals before starting treatment with soluble CD4, but became difficult to isolate soon after treatment had begun. Moreover the diminished growth of both granulocyte-macrophage and erythrocyte progenitor colonies from the bone marrow of these monkeys rose to normal levels during treatment. These findings indicate that soluble CD4 could prove valuable in the treatment of AIDS.
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Author notes
- Theresa Liu and Richard A. Fisher: Biogen Research Corporation, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
- Norman L. Letvin: To whom correspondence should be addressed.
Authors and Affiliations
- Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts, 01772, USA
Mamoru Watanabe, Keith A. Reimann, Peter A. DeLong, Theresa Liu, Richard A. Fisher & Norman L. Letvin
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- Mamoru Watanabe
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Watanabe, M., Reimann, K., DeLong, P. et al. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques.Nature 337, 267–270 (1989). https://doi.org/10.1038/337267a0
- Received: 14 October 1988
- Accepted: 08 December 1988
- Issue Date: 19 January 1989
- DOI: https://doi.org/10.1038/337267a0