Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques (original) (raw)

Nature volume 337, pages 267–270 (1989)Cite this article

Abstract

The CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV-1)1 and a soluble truncated form of CD4 produced by recombinant DNA technology is a potent inhibitor of HIV-1 replication and HIV-1-induced cell fusion _in vitro_2–6. Rhesus monkeys infected with the simian immunodeficiency virus of macaques (SIVMAC), a virus closely related to HIV-1, develop an AIDS-like syndrome, and so provide an important model for the evaluation of potential AIDS therapies7. We have assessed the therapeutic effect of recombinant soluble CD4 in SIVMAC-infected rhesus monkeys. Virus was readily isolated from peripheral blood lymphocytes and bone marrow cells of these animals before starting treatment with soluble CD4, but became difficult to isolate soon after treatment had begun. Moreover the diminished growth of both granulocyte-macrophage and erythrocyte progenitor colonies from the bone marrow of these monkeys rose to normal levels during treatment. These findings indicate that soluble CD4 could prove valuable in the treatment of AIDS.

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References

  1. McDougal, J. S. et al. Science 231, 382–385 (1986).
    Article ADS CAS Google Scholar
  2. Fisher, R. A. et al. Nature 331, 76–78 (1988).
    Article ADS CAS Google Scholar
  3. Hussey, R. E. et al. Nature 331, 78–81 (1988).
    Article ADS CAS Google Scholar
  4. Deen, K. C. et al. Nature 331, 82–84 (1988).
    Article ADS CAS Google Scholar
  5. Traunecker, A., Luke, W. & Karjalainen, K. Nature 331, 84–86 (1988).
    Article ADS CAS Google Scholar
  6. Smith, D. H. et al. Science 238, 1704–1707 (1987).
    Article ADS CAS Google Scholar
  7. Letvin, N. L. et al. Science 230, 71–73 (1985).
    Article ADS CAS Google Scholar
  8. Dalgleish, A. G. et al. Nature 312, 763–766 (1984).
    Article ADS CAS Google Scholar
  9. Klatzmann, D. et al. Nature 312, 767–768 (1984).
    Article ADS CAS Google Scholar
  10. Maddon, P. J. et al. Cell 47, 333–348 (1986).
    Article CAS Google Scholar
  11. Letvin, N. L. in AIDS (ed. Kulstad, R.) (AAAS, Washington D.C., 1989).
    Google Scholar
  12. Fultz, P. N. et al. in Vaccines 88 (ed. Chanock, R. M.) (Cold Spring Harbor Laboratory, New York 1988).
    Google Scholar
  13. Murphey-Corb, M. et al. Nature 321, 435–437 (1986).
    Article ADS CAS Google Scholar
  14. Kannagi, M. et al. J. clin. Invest. 78, 1229–1236 (1986).
    Article CAS Google Scholar
  15. Letvin, N. L. et al. in Vaccines 87 (ed. Chanock, R. M.) (Cold Spring Harbor Laboratory, New York, 1987).
    Google Scholar
  16. Schreiber, Z. A., Loh, S. H., Charles, M. & Abeebe, L. S. Blood 52, 117a (1983).
    Google Scholar
  17. Stella, C. C., Ganser, A. & Hoelzer, D. J. clin. Invest. 80, 286–293 (1987).
    Article CAS Google Scholar
  18. Kannagi, M., Chalifoux, L. V., Lord, C. I. & Letvin, N. L. J. Immun. 140, 2237–2242 (1988).
    CAS PubMed Google Scholar
  19. Fauci, A. S. Science 239, 617–622 (1988).
    Article ADS CAS Google Scholar

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Author notes

  1. Theresa Liu and Richard A. Fisher: Biogen Research Corporation, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
  2. Norman L. Letvin: To whom correspondence should be addressed.

Authors and Affiliations

  1. Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts, 01772, USA
    Mamoru Watanabe, Keith A. Reimann, Peter A. DeLong, Theresa Liu, Richard A. Fisher & Norman L. Letvin

Authors

  1. Mamoru Watanabe
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  2. Keith A. Reimann
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  3. Peter A. DeLong
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  4. Theresa Liu
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  5. Richard A. Fisher
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  6. Norman L. Letvin
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Watanabe, M., Reimann, K., DeLong, P. et al. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques.Nature 337, 267–270 (1989). https://doi.org/10.1038/337267a0

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