Severe immunodeficiency disease induced by a defective murine leukaemia virus (original) (raw)

Nature volume 338, pages 505–508 (1989)Cite this article

Abstract

DIFFERENT classes of retroviruses have been shown to induce immunodeficiency diseases in various animal species1. These animal models may provide an insight into our understanding of AIDS1–3 but, with the exception of one strain of feline leukaemia virus4, the determinants of pathogenicity have not yet been mapped to these viral genomes. The immunodeficiency-inducing feline leukaemia virus is replication-defective4, harbouring the determinant of pathogenicity within its env sequences5. We have studied the Duplan strain of murine leukaemia virus6 which induces, in C57BL/6 mice7–11, a severe immunodeficiency disease with striking similarities to human AIDS2,3,8,9. We have identified the aetiological agent of this murine immunodeficiency disease as another defective retrovirus, with a genome of 4.8 kilobases. Molecular cloning and sequencing of this DNA showed that the pol and env genes have been deleted, but that the complete gag region has been conserved and has a novel sequence encoding the p12 protein. As with the feline leukaemia virus4,5, these results provide evidence for the role of defective retroviruses in inducing immunodeficiency and facilitate the study of the mechanisms underlying the pathogenesis of retrovirus-induced immunodeficiency syndromes, including AIDS.

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Author notes

  1. Douglas C. Aziz
    Present address: Cytometrics Inc., 11575 Sorrento Valley Road, San Diego, California, 92121, USA
  2. Paul Jolicoeur: To whom correspondence should be addressed.

Authors and Affiliations

  1. Laboratory of Molecular Biology, Clinical Research Institute of Montreal, 110 Avenue des Pins ouest, Montréal, Québec, H2W 1R7, Canada
    Douglas C. Aziz, Zaher Hanna & Paul Jolicoeur
  2. Departement de Microbiologie et d'Immunologie, Université de Montréal, Montréal, Québec, H3C 3J7, Canada
    Paul Jolicoeur

Authors

  1. Douglas C. Aziz
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  2. Zaher Hanna
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  3. Paul Jolicoeur
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Aziz, D., Hanna, Z. & Jolicoeur, P. Severe immunodeficiency disease induced by a defective murine leukaemia virus.Nature 338, 505–508 (1989). https://doi.org/10.1038/338505a0

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