Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder (original) (raw)

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Authors and Affiliations

  1. Molecular Neurogenetics Lab., Depts Neurology and General Internal Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, MA, 02114, USA
    P. H. St George-Hyslop, J. L. Haines, J. Growdon, V. A. Fried & J. F. Gusella
  2. Dept Neurology, Boston Univ. School of Medicine, 80 E. Concord Ave., Boston, MA, 02118, USA
    L. A. Farrer & R. H. Myers
  3. Clinical Neuroscience Branch, NINDS, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    R. Polinsky & L. Nee
  4. Depts Neurogenetics and Neurology, Born Bunge Foundation, Univ. Antwerp, 1 Universiteitsplein, Antwerp
    C. Van Broeckhoven, H. Backhovens & J-J. Martin
  5. Dept Neurology, Univ. Brussels, Laarbeeklaan 103/E, B-1090, Brussels, Belgium
    C. Van Broeckhoven, H. Backhovens & J-J. Martin
  6. Depts Biochemistry and Neurology, St Mary's Hospital Medical School, Norfolk Place, London, W2 1PG, UK
    A. Goate, M. Rossor, M. J. Owen, M. Mullan & J. A. Hardy
  7. Center for Research on Neurodegenerative Diseases, Tanz Neuroscience Institute, and Depts Medicine, Physiology, Psychiatry and Obstetrics, Faculty of Medicine, Univ. Toronto, King's College Circle, Toronto, Ontario, Canada, M5S 1A8
    D. R. Crapper McLachlan, M. E. Percy & H. Karlinsky
  8. Depts Psychiatry and Laboratory Medicine, Univ. Minnesota Medical School, 420 Delaware St, Minneapolis, MN, 55455, USA
    H. Orr, S. Rich & L. Heston
  9. Centre Sud, Studio Multicentrico Italiano sulla Demenza, Via dei Campioni, 88046, Lamezia Terme CZ, Italy
    A. C. Bruni & M. Montesi
  10. Dept Neurology, Universita di Firenze, viale Morgagni 85, Firenze, Italy
    S. Sorbi, M. Mortilla & N. Nacmias
  11. Istituto di Clinica delle Malattie Nervose, Univ. Torino, via Cherasco 15, 10126, Torino, Italy
    I. Rainero
  12. Laboratoire de Neurohistologie, Ecole Pratique des Hautes Etudes and INSERM U106, Hopital de la Salpetriere, 75651, Paris, 13, France
    J.-F. Foncin
  13. Dept Neurology, Univ. Massachusetts Medical School, Lake Ave. S., Worcester, MA, 01605, USA
    D. Pollen
  14. Institute Mexicano del Seguro Social, Division de Genetica, Unidad de Investigacion Biomedica de Occidente, APDO 1-38-38, Guadalajara, Jalisco, Mexico
    J-M. Cantu
  15. Dipartimento di Patologia Umana ed Ereditaria, Universita di Pavia, via Forlanini, 27100, Pavia, Italy
    R. Tupler
  16. Clinica Neurologica, Universita di Brescia, Piazza Spedale Civili 1, 25125, Brescia, Italy
    R. Tupler
  17. All Union Center for Mental Health Center, USSR Acad. Medical Sciences, Zagorodnoe sh. 2, Moscow, 113-152, USSR
    N. Voskresenskaya
  18. The Neurological Institute, Columbia Univ. College of Physicians and Surgeons, 710 W. 168th St, New York, NY, 10032, USA
    R. Mayeux

Authors

  1. P. H. St George-Hyslop
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  2. J. L. Haines
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  3. L. A. Farrer
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  4. R. Polinsky
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  5. C. Van Broeckhoven
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  6. A. Goate
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  7. D. R. Crapper McLachlan
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  8. H. Orr
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  9. A. C. Bruni
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  10. S. Sorbi
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  11. I. Rainero
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  12. J.-F. Foncin
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  13. D. Pollen
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  14. J-M. Cantu
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  15. R. Tupler
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  16. N. Voskresenskaya
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  17. R. Mayeux
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  18. J. Growdon
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  19. V. A. Fried
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  20. R. H. Myers
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  21. L. Nee
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  22. H. Backhovens
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  23. J-J. Martin
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  24. M. Rossor
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  25. M. J. Owen
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  26. M. Mullan
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  27. M. E. Percy
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  28. H. Karlinsky
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  29. S. Rich
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  30. L. Heston
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  31. M. Montesi
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  32. M. Mortilla
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  33. N. Nacmias
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  34. J. F. Gusella
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  35. J. A. Hardy
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St George-Hyslop, P., Haines, J., Farrer, L. et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.Nature 347, 194–197 (1990). https://doi.org/10.1038/347194a0

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