VHL takes HIF’s breath away (original) (raw)

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• Published: 01 July 2000

Nature Cell Biology volume 2, pages E121–E123 (2000)Cite this article

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Abstract

Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.

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Authors and Affiliations

1. the Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058, Basel, Switzerland
   Wilhelm Krek

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1. Wilhelm Krek
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Correspondence toWilhelm Krek.

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Krek, W. VHL takes HIF’s breath away.Nat Cell Biol 2, E121–E123 (2000). https://doi.org/10.1038/35017129

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• Issue Date: 01 July 2000
• DOI: https://doi.org/10.1038/35017129

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