Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo (original) (raw)

References

1. Horvitz, H. R. & Herskowitz, I. Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell 68, 237–255 (1992).
   Article CAS PubMed Google Scholar
2. Rappaport, R. Cytokinesis in animal cells. Int. Rev. Cytol. 31, 169–213 (1971).
   Article CAS PubMed Google Scholar
3. Gönczy, P. & Hyman, A. A. Cortical domains and the mechanisms of asymmetric cell division. Trends Cell Biol. 6, 382–387 (1996).
   Article PubMed Google Scholar
4. Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806–811 (1998).
   Article ADS CAS PubMed Google Scholar
5. Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64–119 (1983).
   Article CAS PubMed Google Scholar
6. Goldstein, B. & Hird, S. N. Specification of the anteroposterior axis in Caenorhabditis elegans. Development 122, 1467–1474 (1996).
   CAS PubMed Google Scholar
7. Kemphues, K. J. & Strome, S. in C. elegans II (eds Riddle, D. L., Blumenthal, T., Meyer, B. J. & Priess, J. R.) 335–359 (Cold Spring Harbor Laboratory, New York, 1997).
   Google Scholar
8. Albertson, D. Formation of the first cleavage spindle in nematode embryos. Dev. Biol. 101, 61–72 (1984).
   Article CAS PubMed Google Scholar
9. Leslie, R. J. & Pickett, H. J. Ultraviolet microbeam irradiations of mitotic diatoms: investigation of spindle elongation. J. Cell Biol. 96, 548–561 (1983).
   Article CAS PubMed Google Scholar
10. Aist, J. R. & Berns, M. W. Mechanics of chromosome separation during mitosis in Fusarium (Fungi imperfecti): new evidence from ultrastructural and laser microbeam experiments. J. Cell Biol. 91, 446–458 (1981).
    Article CAS PubMed Google Scholar
11. Aist, J. R., Liang, H. & Berns, M. W. Astral and spindle forces in PtK2 cells during anaphase B: a laser microbeam study. J. Cell Sci. 104, 1207–1216 (1993).
    PubMed Google Scholar
12. Waters, J. C., Cole, R. W. & Rieder, C. L. The force-producing mechanism for centrosome separation during spindle formation in vertebrates is intrinsic to each aster. J. Cell Biol. 122, 361–372 (1993).
    Article CAS PubMed Google Scholar
13. Wordeman, L. & Mitchison, T. J. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J. Cell Biol. 128, 95–104 (1995).
    Article CAS PubMed Google Scholar
14. Wein, H., Foss, M., Brady, B. & Cande, W. Z. DSK1, a novel kinesin-related protein from the diatom Cylindrotheca fusiformis that is involved in anaphase spindle elongation. J. Cell Biol. 133, 595–604 (1996).
    Article CAS PubMed Google Scholar
15. Desai, A., Verma, S., Mitchison, T. J. & Walczak, C. E. Kin I kinesins are microtubule-destabilizing enzymes. Cell 96, 69–78 (1999).
    Article CAS PubMed Google Scholar
16. Gönczy, P. et al. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408, 331–336 (2000).
    Article ADS PubMed Google Scholar
17. Kemphues, K. J., Priess, J. R., Morton, D. G. & Cheng, N. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52, 311–320 (1988).
    Article CAS PubMed Google Scholar
18. Etemad-Moghadam, B., Guo, S. & Kemphues, K. J. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell 83, 743–752 (1995).
    Article CAS PubMed Google Scholar
19. Boyd, L., Guo, S., Levitan, D., Stinchcomb, D. T. & Kemphues, K. J. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development 122, 3075–3084 (1996).
    CAS PubMed Google Scholar
20. Cheng, N. N., Kirby, C. M. & Kemphues, K. J. Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3. Genetics 139, 549–559 (1995).
    CAS PubMed PubMed Central Google Scholar
21. Hill, D. P. & Strome, S. An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes. Dev. Biol. 125, 75–84 (1988).
    Article CAS PubMed Google Scholar
22. Hyman, A. A. & White, J. G. Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans. J. Cell Biol. 105, 2123–2135 (1987).
    Article CAS PubMed Google Scholar
23. Lee, L. et al. Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. Science 287, 2260–2262 (2000).
    Article ADS CAS PubMed Google Scholar
24. Korinek, W. S., Copeland, M. J., Chaudhuri, A. & Chant, J. Molecular linkage underlying microtubule orientation toward cortical sites in Yeast. Science 287, 2257–2259 (2000).
    Article ADS CAS PubMed Google Scholar
25. Rose, L. S. & Kemphues, K. The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo. Development 125, 1337–1346 (1998).
    CAS PubMed Google Scholar
26. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71–94 (1974).
    CAS PubMed PubMed Central Google Scholar
27. Morton, D. G., Roos, J. M. & Kemphues, K. J. par-4, a gene required for cytoplasmic localisation and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics 130, 771–790 (1992).
    CAS PubMed PubMed Central Google Scholar
28. Gönczy, P. et al. Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis. J. Cell Biol. 144, 927–946 (1999).
    Article PubMed PubMed Central Google Scholar
29. Raich, W. B., Moran, A. N., Rothman, J. H. & Hardin, J. Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Mol. Biol. Cell 9, 2037–2049 (1998).
    Article CAS PubMed PubMed Central Google Scholar
30. Powers, J., Bossinger, O., Rose, D., Strome, S. & Saxton, W. A nematode kinesin required for cleavage furrow advancement. Curr. Biol. 8, 1133–1136 (1998).
    Article CAS PubMed PubMed Central Google Scholar

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