Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation (original) (raw)

References

  1. Valitutti, S., Mulle, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide–MHC complexes. Nature 375, 148–151 (1995).
    Article ADS CAS Google Scholar
  2. Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104–106 (1996).
    Article ADS CAS Google Scholar
  3. Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283, 680–682 (1999).
    Article ADS CAS Google Scholar
  4. Monks, C. R., Feiberg, B. A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82–86 (1998).
    Article ADS CAS Google Scholar
  5. Wulfing, C. & Davis, M. M. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282, 2266–2269 (1998).
    Article ADS CAS Google Scholar
  6. Cummings, R. D. & Kornfeld, S. The distribution of repeating Gal β1-4GlcNAc β1-3 sequences in asparagine-linked oligosaccharides of the mouse lymphoma cell line BW5147 and PHAR 2.1. J. Biol. Chem. 259, 6253–6260 (1984).
    CAS PubMed Google Scholar
  7. Sato, S. & Hughes, R. C. Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin. J. Biol. Chem. 267, 6983–6990 (1992).
    CAS PubMed Google Scholar
  8. Knibbs, R. N., Agrwal, N., Wang, J. L. & Goldstein, I. J. Carbohydrate-binding protein 35. II. Analysis of the interaction of the recombinant polypeptide with saccharides. J. Biol. Chem. 268, 14940–14947 (1993).
    CAS PubMed Google Scholar
  9. Perillo, N. L., Pace, K. E., Seilhamer, J. J. & Baum, L. G. Apoptosis of T cells mediated by galectin-1. Nature 378, 736–739 (1995).
    Article ADS CAS Google Scholar
  10. Vespa, G. N. et al. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation. J. Immunol. 162, 799–806 (1999).
    CAS PubMed Google Scholar
  11. Karsan, A. et al. Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium. J. Clin. Invest. 101, 2438–2445 (1998).
    Article CAS Google Scholar
  12. Ellies, L. G. et al. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity 9, 881–890 (1998).
    Article CAS Google Scholar
  13. Priatel, J. J. et al. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity 12, 273–283 (2000).
    Article CAS Google Scholar
  14. Wall, K. A., Pierce, J. D. & Elbein, A. D. Inhibitors of glycoprotein processing alter T-cell proliferative responses to antigen and to interleukin 2. Proc. Natl Acad. Sci. USA 85, 5644–5648 (1988).
    Article ADS CAS Google Scholar
  15. Cummings, R. D., Trowbridge, I. S. & Kornfeld, S. A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc:α-D-mannoside β1,6 N-acetylglucosaminyltransferase. J. Biol. Chem. 257, 13421–13427 (1982).
    CAS PubMed Google Scholar
  16. Granovsky, M. et al. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nature Med. 6, 306–312 (2000).
    Article CAS Google Scholar
  17. Lafaille, J. J., Nagashima, K., Katsuki, M. & Tonegawa, S. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78, 399–408 (1994).
    Article CAS Google Scholar
  18. Downward, J., Graves, J. D., Warne, P. H., Rayter, S. & Cantrell, D. A. Stimulation of p21_ras_ upon T-cell activation. Nature 346, 719–723 (1990).
    Article ADS CAS Google Scholar
  19. Trevillyan, J. M., Lu, Y. L., Atluru, D., Phillips, C. A. & Bjorndahl, J. M. Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase. J. Immunol. 145, 3223–3230 (1990).
    CAS PubMed Google Scholar
  20. Wang, J. et al. Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. EMBO J. 17, 10–26 (1998).
    Article Google Scholar
  21. Hubbard, S. C., Kranz, D. M., Longmore, G. D., Sitkovsky, M. V. & Eisen, H. N. Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity. Proc. Natl Acad. Sci. USA 83, 1852–1856 (1986).
    Article ADS CAS Google Scholar
  22. Reich, Z. et al. Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617–620 (1997).
    Article ADS CAS Google Scholar
  23. Reif, K. & Cantrell, D. A. Networking Rho family GTPases in lymphocytes. Immunity 8, 395–401, (1998).
    Article CAS Google Scholar
  24. Rudd, P. M. et al. Roles for glycosylation of cell surface receptors involved in cellular immune recognition. J. Mol. Biol. 293, 351–366 (1999).
    Article CAS Google Scholar
  25. Pace, K. E., Lee, C., Stewart, P. L. & Baum, L. G. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. J. Immunol. 163, 3801–3811 (1999).
    CAS PubMed Google Scholar
  26. Chung, C. D., Patel, V. P., Moran, M., Lewis, L. A. & Carrie Miceli, M. Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction. J. Immunol. 165, 3722–3729 (2000).
    Article CAS Google Scholar
  27. Offner, H. et al. Recombinant human beta-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 28, 177–184 (1990).
    Article CAS Google Scholar
  28. Barkal, N. & Leibler, S. Robustness in simple biochemical networks. Nature 387, 913–917 (1997).
    Article ADS Google Scholar
  29. Oliveira-dos-Santos, A. J. et al. CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis. J. Immunol. 162, 4490–4495 (1999).
    CAS PubMed Google Scholar
  30. Moloney, D. J. et al. Fringe is a glycosyltransferase that modifies Notch. Nature 406, 369–375 (2000).
    Article ADS CAS Google Scholar

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